{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:47:35Z","timestamp":1787500055166,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071914"],"award-info":[{"award-number":["82071914"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004147","name":"Tsinghua University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3602500"],"award-info":[{"award-number":["2022YFC3602500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3602503"],"award-info":[{"award-number":["2022YFC3602503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Free\u2010breathing abdominal chemical exchange saturation transfer (CEST) has great potential for clinical application, but its technical implementation remains challenging. This study aimed to propose and evaluate a free\u2010breathing abdominal CEST sequence. The proposed sequence employed respiratory gating (ResGat) to synchronize the data acquisition with respiratory motion and performed a water presaturation module before the CEST saturation to abolish the influence of respiration\u2010induced repetition time variation. In vivo experiments were performed to compare different respiratory motion\u2010control strategies and B0 offset correction methods, and to evaluate the effectiveness and necessity of the quasi\u2010steady\u2010state (QUASS) approach for correcting the influence of the water presaturation module on CEST signal. ResGat with a target expiratory phase of 0.5 resulted in a higher structural similarity index and a lower coefficient of variation on consecutively acquired CEST S0 images than breath\u2010holding (BH) and respiratory triggering (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). B0 maps derived from the abdominal CEST dataset itself were more stable for B0 correction, compared with the separately acquired B0 maps by a dual\u2010echo time scan and B0 maps derived from the water saturation shift referencing approach. Compared with BH, ResGat yielded more homogeneous magnetization transfer ratio asymmetry maps at 3.5\u2009ppm (standard deviation: 3.96% vs. 3.19%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.036) and a lower mean squared difference between scan and rescan (27.52\u2031 vs. 16.82\u2031,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). The QUASS approach could correct the water presaturation\u2010induced CEST signal change, but its necessity for in vivo scanning needs further verification. The proposed free\u2010breathing abdominal CEST sequence using ResGat had an acquisition efficiency of approximately four times that using BH. In conclusion, the proposed free\u2010breathing abdominal CEST sequence using ResGat and water presaturation has a higher acquisition efficiency and image quality than abdominal CEST using BH.\n                  <\/jats:p>","DOI":"10.1002\/nbm.5134","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T02:14:45Z","timestamp":1709950485000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Free\u2010breathing abdominal chemical exchange saturation transfer imaging using water presaturation and respiratory gating at 3.0\u2009T"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7975-2528","authenticated-orcid":false,"given":"Zhensen","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Science and Technology for Brain\u2010Inspired Intelligence Fudan University  Shanghai China"},{"name":"Key Laboratory of Computational Neuroscience and Brain\u2010Inspired Intelligence (Fudan University), Ministry of Education  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging Research, Department of Biomedical Engineering School of Medicine Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishi","family":"Wang","sequence":"additional","affiliation":[{"name":"Philips Healthcare  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Medical Technology Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Chen","sequence":"additional","affiliation":[{"name":"Philips Healthcare  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology for Brain\u2010Inspired Intelligence Fudan University  Shanghai China"},{"name":"Key Laboratory of Computational Neuroscience and Brain\u2010Inspired Intelligence (Fudan University), Ministry of Education  Shanghai China"},{"name":"Human Phenome Institute Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Song","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging Research, Department of Biomedical Engineering School of Medicine Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22761"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25838"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111559"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4906"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010015\u20103972\u20100"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307\u2010015\u20100887\u20108"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.578985"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015151161"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25832"},{"key":"e_1_2_9_11_1","unstructured":"KeuppJ JiaG DimitrovI et al.Prospecitively motion compensated amide proton transfer MRI for body oncology Proceeding of ISMRM 2013 Salt Lake City Utah USA P2532."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26323"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29470"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28653"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1994.1048"},{"key":"e_1_2_9_16_1","unstructured":"ZaissM.CEST sources.BM_sim_fit.https:\/\/github.com\/cest-sources\/BM_sim_fit. 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