{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T23:31:26Z","timestamp":1789255886848,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["BRC\u20101215\u201020014"],"award-info":[{"award-number":["BRC\u20101215\u201020014"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present a sequence building block (SBB) that embeds magnetic resonance spectroscopy (MRS) into another sequence on the Siemens VE platform without any custom hardware. This enables dynamic studies such as functional MRS (fMRS), dynamic shimming and frequency correction, and acquisition of navigator images for motion correction. The SBB supports nonlocalised spectroscopy (free induction decay), STimulated Echo Acquisition Mode single voxel spectroscopy, and 1D, 2D and 3D phase\u2010encoded chemical shift imaging. It can embed <jats:sup>1<\/jats:sup>H or X\u2010nuclear MRS into a <jats:sup>1<\/jats:sup>H sequence; and <jats:sup>1<\/jats:sup>H\u2010MRS into an X\u2010nuclear sequence. We demonstrate integration into the vendor's gradient\u2010recalled echo sequence. We acquire test data in phantoms with three coils (<jats:sup>31<\/jats:sup>P\/<jats:sup>1<\/jats:sup>H, <jats:sup>13<\/jats:sup>C\/<jats:sup>1<\/jats:sup>H and <jats:sup>2<\/jats:sup>H\/<jats:sup>1<\/jats:sup>H) and in two volunteers on a 7\u2010T Terra MRI scanner. Fifteen lines of code are required to insert the SBB into a sequence. Spectra and images are acquired successfully in all cases in phantoms, and in human abdomen and calf muscle. Phantom comparison of signal\u2010to\u2010noise ratio and linewidth showed that the SBB has negligible effects on image and spectral quality, except that it sometimes produces a nuclear Overhauser effect (NOE) signal enhancement for multinuclear applications in line with conventional <jats:sup>1<\/jats:sup>H NOE pulses. Our new SBB embeds MRS into a host imaging or spectroscopy sequence in 15 lines of code. It allows homonuclear and heteronuclear interleaving. The package is available through the standard C2P procedure. We hope this will lower the barrier for entry to studies applying dynamic fMRS and for online motion correction and B<jats:sub>0<\/jats:sub>\u2010shim updating.<\/jats:p>","DOI":"10.1002\/nbm.5165","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:55:06Z","timestamp":1716944106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sequence building block for magnetic resonance spectroscopy on Siemens VE\u2010series scanners"],"prefix":"10.1002","volume":"37","author":[{"given":"Jabrane","family":"Karkouri","sequence":"first","affiliation":[{"name":"Wolfson Brain Imaging Center University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1275-1197","authenticated-orcid":false,"given":"Christopher T.","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Wolfson Brain Imaging Center University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119382461"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13130531"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2011.08.002"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2010.04.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.07.017"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12307"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4246"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24922"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1772"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.841"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.120250"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019191242"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aat7314"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2020.07.003"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4735"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600383"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.09.034"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29221"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730\u2010725x(86)91044\u20101"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910320114"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1994.1050"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350404"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29196"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28073"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3328"},{"issue":"5","key":"e_1_2_11_27_1","first-page":"751","article-title":"An interleaved heteronuclear NMRI\u2010NMRS approach to non\u2010invasive investigation of exercising human skeletal muscle","volume":"43","author":"Brillault\u2010Salvat C","year":"1997","journal-title":"Cell Mol Biol"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20649"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334\u2010005\u20100014\u2010y"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21188"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00887.2001"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28088"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26841"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28684"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3368"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmr.b.21347"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1565"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12121153"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.09.032"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1469"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3842"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26056"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2017.11.005"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0730\u2010725x(99)00132\u20100"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117358"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26576"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185356"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910230102"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27886"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.120194"},{"key":"e_1_2_11_51_1","volume-title":"Paper presented at: International Society of Magnetic Resonance in Medicine","author":"Klodowski K","year":"2022"},{"key":"e_1_2_11_52_1","volume-title":"Paper presented at: ISMRM; 2022; London, UK","author":"Poli S"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.5165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:58:27Z","timestamp":1760954307000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.5165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,28]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/nbm.5165"],"URL":"https:\/\/doi.org\/10.1002\/nbm.5165","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,28]]},"assertion":[{"value":"2023-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5165"}}