{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:21:49Z","timestamp":1770906109678,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Magnetic resonance imaging (MRI) and cognitive profiles in patients with mild traumatic brain injury (mTBI) are often discordant. Conventional MRI seldom captures the full extent of pathological changes in the normal\u2010appearing white matter (NAWM). The divided subtracted inversion recovery (dSIR) technique may enhance T1 differences in NAWM, making them easily visible. We aimed to implement dSIR on a clinical scanner and tested results in mTBI patients. To produce dSIR images, Inversion Recovery\u2010Turbo Spin Echo sequences were modified using six different inversion times (TI) on a 3\u2010T scanner in healthy participants and patients with mTBI. The multiple TIs determined normal white (TI<jats:sub>short<\/jats:sub>) and gray matter (TI<jats:sub>long<\/jats:sub>) nulling points in healthy subjects, which were used to create dSIR images. In one patient, the protocol was repeated at 3\u2009months to identify changes after rehabilitation. Diffusion tensor imaging (DTI)\u2010derived mean diffusivity (MD) and fractional anisotropy (FA) maps were aligned to dSIR images to ensure that signal was not artefactual. Ten healthy participants (five females; age 24\u2009\u00b1\u20093 [95% CI: 21, 26] years) were included. TI<jats:sub>short<\/jats:sub> and TI<jats:sub>long<\/jats:sub> were set at 450 and 750\u2009ms, respectively. In both patients (one male, age 17 years; one female, age 14 years), dSIR images revealed areas with increased T1 in the NAWM not visible on conventional MRI. dSIR\u2010based hyperintensities corresponded to elevated MD and reduced FA. Substantial changes were found at follow\u2010up with improvement in DTI\u2010based parameters. dSIR images enhance subtle changes in the NAWM of patients with mTBI by amplifying their intrinsic T1 signal.<\/jats:p>","DOI":"10.1002\/nbm.5175","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T07:19:23Z","timestamp":1715930363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Enhancing T1 signal of normal\u2010appearing white matter with divided subtracted inversion recovery: A pilot study in mild traumatic brain injury"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6044-9999","authenticated-orcid":false,"given":"Letizia","family":"Losa","sequence":"first","affiliation":[{"name":"Neuroimaging Unit Scientific Institute IRCCS E. 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