{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:35:35Z","timestamp":1790872535475,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB030549"],"award-info":[{"award-number":["R01EB030549"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB031083"],"award-info":[{"award-number":["R01EB031083"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41EB017183"],"award-info":[{"award-number":["P41EB017183"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This work proposes MP\u2010Grasp4D (magnetization\u2010prepared golden\u2010angle radial sparse parallel 4D) MRI, a free\u2010breathing, inversion recovery (IR)\u2010prepared, time\u2010resolved 4D MRI technique with improved T1\u2010weighted contrast. MP\u2010Grasp4D MRI acquisition incorporates IR preparation into a radial gradient echo sequence. MP\u2010Grasp4D employs a golden\u2010angle navi\u2010stack\u2010of\u2010stars sampling scheme, where imaging data of rotating radial stacks and navigator stacks (acquired at a consistent rotation angle) are alternately acquired. The navigator stacks are used to estimate a temporal basis for low\u2010rank subspace\u2010constrained reconstruction. This allows for the simultaneous capture of both IR\u2010induced contrast changes and respiratory motion. One temporal frame of the imaging volume in MP\u2010Grasp4D MRI is reconstructed from a single stack and an adjacent navigator stack on average, resulting in a nominal temporal resolution of 0.16\u2009seconds per volume. Images corresponding to the optimal inversion time (TI) can be retrospectively selected for providing the best image contrast. Reader studies were conducted to assess the performance of MP\u2010Grasp4D MRI in liver imaging across 30 subjects in comparison with standard Grasp4D MRI without IR preparation. MP\u2010Grasp4D MRI received significantly higher scores (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) than Grasp4D in all assessment categories. There was a moderate to almost perfect agreement (kappa coefficient from 0.42 to 0.9) between the two readers for image quality assessment. When the scan time is reduced, MP\u2010Grasp4D MRI preserves image contrast and quality, demonstrating additional acceleration capability. MP\u2010Grasp4D MRI improves T1\u2010weighted contrast for free\u2010breathing time\u2010resolved 4D MRI and eliminates the need for explicit motion compensation. This method is expected to be valuable in different MRI applications such as MR\u2010guided radiotherapy.<\/jats:p>","DOI":"10.1002\/nbm.5247","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T03:55:07Z","timestamp":1724644507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Free\u2010breathing time\u2010resolved 4D MRI with improved T1\u2010weighting contrast"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6023-1033","authenticated-orcid":false,"given":"Jingjia","family":"Chen","sequence":"first","affiliation":[{"name":"Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology New York University Grossman School of Medicine  New York New York USA"},{"name":"Center for Advanced Imaging Innovation and Research (CAI<sup>2<\/sup>R), Department of Radiology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Xia","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai Biomedical Engineering and Imaging Institute  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchan","family":"Huang","sequence":"additional","affiliation":[{"name":"Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology New York University Grossman School of Medicine  New York New York USA"},{"name":"Center for Advanced Imaging Innovation and Research (CAI<sup>2<\/sup>R), Department of Radiology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Shanbhogue","sequence":"additional","affiliation":[{"name":"Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology New York University Grossman School of Medicine  New York New York USA"},{"name":"Center for Advanced Imaging Innovation and Research (CAI<sup>2<\/sup>R), Department of Radiology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hersh","family":"Chandarana","sequence":"additional","affiliation":[{"name":"Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology New York University Grossman School of Medicine  New York New York USA"},{"name":"Center for Advanced Imaging Innovation and Research (CAI<sup>2<\/sup>R), Department of Radiology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-7645","authenticated-orcid":false,"given":"Li","family":"Feng","sequence":"additional","affiliation":[{"name":"Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology New York University Grossman School of Medicine  New York New York USA"},{"name":"Center for Advanced Imaging Innovation and Research (CAI<sup>2<\/sup>R), Department of Radiology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26745"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26221"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/ryct.2020190205"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25450"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4409"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2016.12.021"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27811"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26245"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.03.021"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010020\u201006890\u2010x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2022.106708"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4927252"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/aae56d"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29450"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14023"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims.2019.06.23"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/abfada"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25665"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000619"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01024"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2020.05.002"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24980"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4844"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29700"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.182.3.1535892"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880010509"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26392"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28187"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27903"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27030"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(200005)43:5<682::AID-MRM10>3.0.CO;2-G"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2012.031"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28679"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29131"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25161"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2022.08.002"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2016.03.007"},{"key":"e_1_2_10_39_1","unstructured":"SolomonE BaeJ ZanE MoyL GeY FengL KimG. SGRASP\u2010Pro+: GRASP reconstruction with locally low\u2010rank subspace constraint for DCE\u2010MRI. In:Proceedings of the Joint Annual Meeting ISMRM\u2010ESMRMB 2022 & ISMRT Annual Meeting 2022:1603."},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.06.007"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.10.020"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.5247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:18:04Z","timestamp":1760966284000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.5247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,26]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/nbm.5247"],"URL":"https:\/\/doi.org\/10.1002\/nbm.5247","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,26]]},"assertion":[{"value":"2024-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5247"}}