{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:44:20Z","timestamp":1761007460188,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01NS108452","5R01AG064093","1RF1AG082257","P41 EB015909","U54 HD079123","S10OD021648"],"award-info":[{"award-number":["1R01NS108452","5R01AG064093","1RF1AG082257","P41 EB015909","U54 HD079123","S10OD021648"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004320","name":"Philips","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Iron Dextran is a widely used iron oxide compound to treat iron\u2010deficiency anemia patients in the clinic. Similar to other iron oxide compounds such as Ferumoxytol, it can also be used off\u2010label as an intravascular magnetic resonance imaging (MRI) contrast agent due to its strong iron\u2010induced T2 and T2* shortening effects. In this study, we seek to evaluate the feasibility of using Iron Dextran enhanced multi\u2010echo susceptibility weighted imaging (SWI) MRI at 7T to image arterial and venous blood vessels in the human brain. Phantom experiments were performed to measure the r2* relaxivity for Iron Dextran in blood, based on which the SWI sequence was optimized. Pre\u2010 and post\u2010infusion MR images were acquired in human subjects from which maps of arteries and veins were extracted. The post\u2010contrast SWI images showed enhanced susceptibility difference between blood and the surrounding tissue in both arteries and veins. Our results showed that the proposed Iron Dextran enhanced multi\u2010echo SWI approach allowed the visualization of blood vessels with diameters down to ~100\u2009\u03bcm, including small blood vessels supplying and draining small brain structures such as the hippocampus. We conclude that Iron Dextran can be an alternative iron\u2010based MRI contrast agent for blood vessel imaging in the human brain.<\/jats:p>","DOI":"10.1002\/nbm.5251","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T22:15:33Z","timestamp":1724710533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Imaging arterial and venous vessels using Iron Dextran enhanced multi\u2010echo 3D gradient echo MRI at 7T"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7972-6573","authenticated-orcid":false,"given":"Yinghao","family":"Li","sequence":"first","affiliation":[{"name":"F.M. 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Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Department of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, International Science and Technology, Cooperation base of Child development and Critical Disorders Chongqing Key Laboratory of Child, Neurodevelopment and Cognitive Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Paez","sequence":"additional","affiliation":[{"name":"F.M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Institute  Baltimore Maryland USA"},{"name":"Division of MRI Research, Russell H. 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