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The changes can be explained by small differences in T<jats:sub>1<\/jats:sub>; however, to date, there has been no independent validation of the technique using a standard reference. The present study develops the theory of the dSIR signal and performs validation using the NIST\/ISMRM T<jats:sub>1<\/jats:sub> phantom. Non\u2010idealities are explored, including the influence of noise bias and finite repetition time (TR), which leads to the introduction of an optimally efficient TR for inversion recovery acquisitions. 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