{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:47Z","timestamp":1786978247238,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["CRSII5\u2010180365"],"award-info":[{"award-number":["CRSII5\u2010180365"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Spin\u2010lock (SL) pulses have been proposed to directly detect neuronal activity otherwise inaccessible through standard functional magnetic resonance imaging. However, the practical limits of this technique remain unexplored. Key challenges in SL\u2010based detection include ultra\u2010weak signal variations, sensitivity to magnetic field inhomogeneities, and potential contamination from blood oxygen level\u2010dependent effects, all of which hinder the reliable isolation of neuronal signals. This pilot study evaluates the performance of the stimulus\u2010induced rotary saturation (SIRS) technique to map visual stimulation response in the human cortex. A rotary echo spin\u2010lock (RESL) preparation followed by a 2D echo planar imaging readout was used to investigate 12 healthy subjects at rest and during continuous exposure to 8\u00a0Hz flickering light. The SL amplitude was fixed to the target neuroelectric oscillations at that frequency. The signal variance was used as contrast metric, and two alternative post\u2010processing pipelines (regression\u2010filtering\u2010rectification and normalized subtraction) were statistically evaluated. Higher variance in the SL signal was detected in four of the 12 subjects. Although group\u2010level analysis indicated activation in the occipital pole, analysis of variance revealed that this difference was not statistically significant, highlighting the need for comparable control measures and more robust preparations. Further optimization in sensitivity and robustness is required to noninvasively detect physiological neuroelectric activity in the human brain.<\/jats:p>","DOI":"10.1002\/nbm.5280","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:49:36Z","timestamp":1730767776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Stimulus\u2010induced rotary saturation imaging of visually evoked response: A pilot study"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0695-0229","authenticated-orcid":false,"given":"Milena","family":"Capiglioni","sequence":"first","affiliation":[{"name":"Support Centre for Advanced Neuroimaging Institute for Diagnostic and Interventional Neuroradiology, University of Bern  Bern Switzerland"},{"name":"Graduate School for Cellular and Biomedical Sciences (GCB) University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Beisteiner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Laboratory for Functional Brain Diagnostics and Therapy, High Field MR Center Medical University of Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Lima","family":"Cardoso","sequence":"additional","affiliation":[{"name":"High Field MR Center, Department of Biomedical Imaging and Image\u2010guided Therapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Turco","sequence":"additional","affiliation":[{"name":"Support Centre for Advanced Neuroimaging Institute for Diagnostic and Interventional Neuroradiology, University of Bern  Bern Switzerland"},{"name":"Graduate School for Cellular and Biomedical Sciences (GCB) University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baudouin","family":"Jin","sequence":"additional","affiliation":[{"name":"Support Centre for Advanced Neuroimaging Institute for Diagnostic and Interventional Neuroradiology, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Support Centre for Advanced Neuroimaging Institute for Diagnostic and Interventional Neuroradiology, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Daniel","family":"Robinson","sequence":"additional","affiliation":[{"name":"High Field MR Center, Department of Biomedical Imaging and Image\u2010guided Therapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Federspiel","sequence":"additional","affiliation":[{"name":"Support Centre for Advanced Neuroimaging Institute for Diagnostic and Interventional Neuroradiology, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Trattnig","sequence":"additional","affiliation":[{"name":"High Field MR Center, Department of Biomedical Imaging and Image\u2010guided Therapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Wiest","sequence":"additional","affiliation":[{"name":"Support Centre for Advanced Neuroimaging Institute for Diagnostic and Interventional Neuroradiology, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.08.065"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06976"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.12.039"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1103\/RevModPhys.65.413"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00076"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600644103"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117318"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abh4340"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1162\/imag_a_00013"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adl0999"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adl2034"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10159"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10494"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.010"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003146107"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2018.07.004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2020.106828"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201021232\u20101"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2015.11.007"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-19275-5"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3241"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.14581\/jer.19001"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00870.2007"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.05.011"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016150368"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.13001"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16270"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP275413"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013\u20109580.2005.66104.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000806"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100\u2010879X2004000600014"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.10.006296"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.10.045"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_2_10_36_1","unstructured":"SPM.Statistical Parametric Mapping.https:\/\/www.fil.ion.ucl.ac.uk\/spm\/"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27654"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.010"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25159"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25553"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2012.04.008"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210100682"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.5280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:41:24Z","timestamp":1760971284000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.5280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,4]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/nbm.5280"],"URL":"https:\/\/doi.org\/10.1002\/nbm.5280","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,4]]},"assertion":[{"value":"2024-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5280"}}