{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T23:34:09Z","timestamp":1770766449548,"version":"3.50.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the association between the fatty acid composition of abdominal adipose tissue in NAFLD patients using chemical shift\u2013encoded MRI and the development of insulin resistance and T2DM. We enrolled 231 subjects with NAFLD who underwent both abdominal magnetic resonance spectroscopy and chemical shift\u2013encoded MRI: comprising of 49 T2DM patients and 182 subjects without. MRI\u2010 and MRS\u2010based liver fat fraction was measured from a circular region of interest on the right lobe of the liver. The abdominal fatty acid compositions were measured at the umbilical level with chemical shift\u2010encoded MRI. Bland\u2010Altman analysis, Student's t test, Mann\u2013Whitney U test, and Spearman correlation analysis were performed. The logistic regression was applied to identify the independent factors for T2DM. Then, the predictive performance was assessed by Receiver operating characteristic curve analyses. An excellent agreement was found between liver fat fraction measured by MRS and MRI. (slope\u2009=\u20090.8; bias\u2009=\u20100.92%). In, patients with T2DM revealed lower fractions of mono\u2010unsaturated fatty acid (F<jats:sub>mufa<\/jats:sub>) (33.68\u2009\u00b1\u200910.62 vs 38.62\u2009\u00b1\u200912.21, P =.0089) and higher fractions of saturated fatty acid (F<jats:sub>sfa<\/jats:sub>) (34.11\u2009\u00b1\u20099.746 vs 31.25\u2009\u00b1\u20098.66, <jats:italic>P<\/jats:italic> =.0351) of visceral fat tissue compared with patients without. BMI, HDL\u2010c, <jats:italic>F<\/jats:italic><jats:sub>mufa<\/jats:sub> and <jats:italic>F<\/jats:italic><jats:sub>sfa<\/jats:sub> of visceral fat were independent factors for T2DM. Furthermore, F<jats:sub>sfa<\/jats:sub>\u2010S% was positively correlated with liver enzyme levels (<jats:italic>P<\/jats:italic> =.003 and 0.04). However, F<jats:sub>mufa<\/jats:sub>\u2010V% was negatively correlated with fasting blood glucose, HbA1c and HOMA\u2010IR (<jats:italic>P<\/jats:italic>\u2009=.004, <jats:italic>P<\/jats:italic>\u2009=.001 and <jats:italic>P<\/jats:italic>\u2009=.03 respectively). Hence, the evaluation of fatty acid compositions of abdominal fat tissue using chemical shift\u2013encoded MRI may have a predictive value for T2DM in patients with NAFLD.<\/jats:p>","DOI":"10.1002\/nbm.5290","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T01:53:43Z","timestamp":1731030823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fatty acid composition evaluation of abdominal adipose tissue using chemical shiftencoded MRI: Association with diabetes"],"prefix":"10.1002","volume":"38","author":[{"given":"Dingxia","family":"Liu","sequence":"first","affiliation":[{"name":"Shanghai Institute of Medical Imaging Dept. of Radiology, Zhongshan Hospital of Fudan University, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minyan","family":"Yin","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Medical 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