{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T08:57:14Z","timestamp":1785920234970,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 EB027061"],"award-info":[{"award-number":["P41 EB027061"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AG052564"],"award-info":[{"award-number":["U01AG052564"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG055591"],"award-info":[{"award-number":["R01 AG055591"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016366","name":"V\u0161eobecn\u00e1 Fakultn\u00ed Nemocnice v Praze","doi-asserted-by":"publisher","award":["MH CZ\u2010DRO\u2010VFN64165"],"award-info":[{"award-number":["MH CZ\u2010DRO\u2010VFN64165"]}],"id":[{"id":"10.13039\/501100016366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Ageing is a complex phenomenon affecting a wide range of coexisting biological processes. The homogeneity of the studied population is an essential parameter for valid interpretations of outcomes. The presented study capitalises on the MRI data available in the Human Connectome Project\u2013Aging (HCP\u2010A) and, within individuals over 55\u2009years of age who passed the HCP\u2010A section criteria, compares a subgroup of 37 apparently neurocognitively healthy individuals selected based on stringent criteria with 37 age and sex\u2010matched individuals still representative of typical ageing but who did not pass the stringent definition of neurocognitively healthy. Specifically, structural scans, diffusion weighted imaging and T1w\/T2w ratio were utilised. Furthermore, data of 26 HCP\u2010A participants older than 90\u2009years as notional \u2018super\u2010agers\u2019 were analysed. The relationship of age and several microstructural MRI metrics (T1w\/T2w ratio, mean diffusivity, intracellular volume fraction and free water volume fraction) differed significantly between typical and healthy ageing cohort in areas highly relevant for ageing such as hippocampus, prefrontal and temporal cortex and cerebellum. However, the trajectories of the healthy ageing population did not show substantially better overlap with the findings in people older than 90 than those of the typical population. Therefore, caution must be exercised in the choice of adequate study group characteristics relevant for respective ageing\u2010related hypotheses. Contrary to typical ageing group, the healthy ageing cohort may show generally stable levels of several MRI metrics of interest.<\/jats:p>","DOI":"10.1002\/nbm.5305","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T19:00:34Z","timestamp":1734030034000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Different Grey Matter Microstructural Patterns in Cognitively Healthy Versus Typical Ageing"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5656-5164","authenticated-orcid":false,"given":"Pavel","family":"Filip","sequence":"first","affiliation":[{"name":"Center for Magnetic Resonance Research (CMRR) University of Minnesota  Minneapolis Minnesota USA"},{"name":"Department of Neurology Charles University, First Faculty of Medicine and General University Hospital  Prague Czech Republic"},{"name":"Department of Cybernetics Czech Technical University in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u00a0Riley","family":"McCarten","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education and Clinical Center Veterans Affairs Medical Center  Minneapolis Minnesota USA"},{"name":"Department of Neurology University of Minnesota Medical School  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hemmy","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education and Clinical Center Veterans Affairs Medical Center  Minneapolis Minnesota USA"},{"name":"Department of Psychiatry University of Minnesota Medical School  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian","family":"Crocker","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research (CMRR) University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wolf","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research (CMRR) University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeromy","family":"Thotland","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research (CMRR) University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzan","family":"Cayci","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalom","family":"Michaeli","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research (CMRR) University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn\u00a0E.","family":"Eberly","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research (CMRR) University of Minnesota  Minneapolis Minnesota USA"},{"name":"Division of Biostatistics, School of Public Health University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Terpstra","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research (CMRR) University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-4516","authenticated-orcid":false,"given":"Silvia","family":"Mangia","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research (CMRR) University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet","author":"Martin C. R.","year":"2021"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270538"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021978"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy104"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.117.6.1169"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617710000706"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4564"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2020.108908"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1099499"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.10.009"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.09.060"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-396460-1.00008-1"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.7.2.204"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2013.07.005"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.02.006"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v042.i08"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.127"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18933"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.05.069"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.10.006"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.060"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2018-0096"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2014.09.010"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2007-12104"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26071"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2019.03.009"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116835"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.02.026"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2180-11.2011"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102234"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.073778"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119743"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13629"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24522"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311\u2010019\u201001015\u20107"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-817990-1.00025-1"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acr116"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42254-021-00326-1"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011214"}],"updated-by":[{"DOI":"10.1002\/nbm.70017","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000}}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.5305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:41:09Z","timestamp":1760971269000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.5305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/nbm.5305"],"URL":"https:\/\/doi.org\/10.1002\/nbm.5305","archive":["Portico"],"relation":{"erratum":[{"id-type":"doi","id":"10.1002\/nbm.70017","asserted-by":"object"}]},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]},"assertion":[{"value":"2024-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5305"}}