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We utilized the brainstem as a seed region for probabilistic tractography based on multishell, multitissue constrained spherical deconvolution in 40 subjects from the Human Connectome Project (HCP). All tractography data were registered into a common space to construct a brainstem fiber cluster atlas. A total of 100 fiber clusters were identified and annotated. Cortical parcellation\u2013based fiber selection was then performed to extract fibers within the annotated clusters that projected to their corresponding cortical regions. This atlas was applied for automatic brainstem fiber bundle segmentation in 10 HCP subjects and 8 patients with brainstem cavernous malformations. The spatial overlap between automatic and manual reconstruction was assessed. 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Additionally, this method is robust in that it allows for the visualization and identification of fiber tracts surrounding brainstem cavernous malformations.<\/jats:p>","DOI":"10.1002\/nbm.5312","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T23:54:42Z","timestamp":1734998082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Automated White Matter Fiber Tract Segmentation for the Brainstem"],"prefix":"10.1002","volume":"38","author":[{"given":"Mingchu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Capital Medical University Xuanwu Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6485-8178","authenticated-orcid":false,"given":"Qingrun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Academy for Advanced Interdisciplinary Science and Technology Zhejiang University of Technology  Hangzhou China"},{"name":"Institute of Information Processing and Automation, College of Information Engineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Academy for Advanced Interdisciplinary Science and Technology Zhejiang University of Technology  Hangzhou China"},{"name":"Institute of Information Processing and Automation, College of Information Engineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Shenzhen Samii Medical Center  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Capital Medical University Xuanwu Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo\u00a0Carvalhal","family":"Ribas","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Hospital das Cl\u00ednicas University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Capital Medical University Xuanwu Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Capital Medical University Xuanwu Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Capital Medical University Xuanwu Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Capital Medical University Xuanwu Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjing","family":"Feng","sequence":"additional","affiliation":[{"name":"Academy for Advanced Interdisciplinary Science and Technology Zhejiang University of Technology  Hangzhou China"},{"name":"Institute of Information Processing and Automation, College of Information Engineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1674-9369","authenticated-orcid":false,"given":"Mengjun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-3078-0"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-10343-2"},{"key":"e_1_2_13_4_1","volume-title":"The Human Nervous System. 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