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Combined <jats:sup>2<\/jats:sup>H and <jats:sup>31<\/jats:sup>P MRS would therefore be of interest for various applications, from cancer to diabetes. Loop coils are commonly used in X\u2010nuclei studies in the human body for both transmit and receive. However, loop coils suffer from limited penetration depth and inhomogeneous B<jats:sub>1<\/jats:sub><jats:sup>+<\/jats:sup> field. The purpose of this work is to develop a double tuned <jats:sup>2<\/jats:sup>H\/<jats:sup>31<\/jats:sup>P whole\u2010body birdcage transmit coil for 7\u2009T for <jats:sup>2<\/jats:sup>H and <jats:sup>31<\/jats:sup>P MRS imaging (MRSI) with homogeneous excitation over a large field\u2010of\u2010view. The performance of the <jats:sup>2<\/jats:sup>H\/<jats:sup>31<\/jats:sup>P birdcage coil was assessed on B<jats:sub>1<\/jats:sub><jats:sup>+<\/jats:sup> fields over a body\u2010sized phantom at <jats:sup>2<\/jats:sup>H and <jats:sup>31<\/jats:sup>P frequencies using an 8\u2010channel <jats:sup>2<\/jats:sup>H\/<jats:sup>31<\/jats:sup>P receive array. Using two elements of the <jats:sup>2<\/jats:sup>H\/<jats:sup>31<\/jats:sup>P receive array, natural abundance <jats:sup>2<\/jats:sup>H and <jats:sup>31<\/jats:sup>P 3D MRSI data at rest were acquired consecutively in the brain and lower leg muscles. Additionally, <jats:sup>2<\/jats:sup>H and <jats:sup>31<\/jats:sup>P 3D MRSI data were acquired from one volunteer 90\u2009min after [6,6\u2032\u2010<jats:sup>2<\/jats:sup>H<jats:sub>2<\/jats:sub>]\u2010glucose intake, using 8\u2010channel <jats:sup>2<\/jats:sup>H\/<jats:sup>31<\/jats:sup>P receive array around the abdomen. The B<jats:sub>1<\/jats:sub><jats:sup>+<\/jats:sup> variation of the whole\u2010body birdcage coil over the phantom was 12.1% for <jats:sup>2<\/jats:sup>H and 19.2% for <jats:sup>31<\/jats:sup>P. High\u2010quality <jats:sup>2<\/jats:sup>H and <jats:sup>31<\/jats:sup>P 3D MRSI data were acquired from the brain and the lower leg. Whole liver coverage was achieved in both <jats:sup>2<\/jats:sup>H and <jats:sup>31<\/jats:sup>P 3D MRSI data. The developed <jats:sup>2<\/jats:sup>H\/<jats:sup>31<\/jats:sup>P whole\u2010body birdcage transmit coil allows simultaneous 3D mapping of glucose and energy metabolism and membrane turnover throughout the human body.<\/jats:p>","DOI":"10.1002\/nbm.5325","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T03:45:06Z","timestamp":1738295106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Development of a Double Tuned <sup>2<\/sup>H\/<sup>31<\/sup>P Whole\u2010Body Birdcage Transmit Coil for <sup>2<\/sup>H and <sup>31<\/sup>P MR Applications From Head to Toe at 7\u2009T"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8862-3012","authenticated-orcid":false,"given":"Ayhan","family":"Gursan","sequence":"first","affiliation":[{"name":"Center for Image Sciences University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7283-0789","authenticated-orcid":false,"given":"Busra","family":"Kahraman\u2010Agir","sequence":"additional","affiliation":[{"name":"Center for Image Sciences University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Gosselink","sequence":"additional","affiliation":[{"name":"Center for Image Sciences University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitri","family":"Welting","sequence":"additional","affiliation":[{"name":"Center for Image Sciences University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3841-0497","authenticated-orcid":false,"given":"Martijn","family":"Froeling","sequence":"additional","affiliation":[{"name":"Center for Image Sciences University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Hoogduin","sequence":"additional","affiliation":[{"name":"Center for Image Sciences University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evita\u00a0C.","family":"Wiegers","sequence":"additional","affiliation":[{"name":"Center for Image Sciences University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4756-4474","authenticated-orcid":false,"given":"Jeanine\u00a0J.","family":"Prompers","sequence":"additional","affiliation":[{"name":"Center for Image Sciences University Medical Center Utrecht  Utrecht The Netherlands"},{"name":"Departments of Human Biology and Imaging, NUTRIM Institute of Nutrition and Translational Research in Metabolism Maastricht University Medical Centre+  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis\u00a0W.\u00a0J.","family":"Klomp","sequence":"additional","affiliation":[{"name":"Center for Image Sciences University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aat7314"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims.2017.11.03"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17706444"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1940050303"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/2193-1801-3-634"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2020.07.003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13130757"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4577"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2007.03.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3274"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24423-x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187153"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27103"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24192"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29439"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25171"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27729"},{"issue":"1","key":"e_1_2_8_19_1","first-page":"20","article-title":"The Surface\u2010Coil NMR Receiver in the Presence of Homogeneous B1 Excitation","volume":"64","author":"Crowley M. 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