{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T18:43:26Z","timestamp":1785350606600,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["France 2030"],"award-info":[{"award-number":["France 2030"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Cerebral imaging is crucial in the diagnosis and treatment algorithm of acute stroke to determine salvageable brain tissue. While diffusion MRI is commonly used to define the ischemic core, it cannot reliably distinguish irreversibly damaged from salvageable tissue. We investigated the added value of <jats:sup>23<\/jats:sup>Na MRI to define irreversible necrotic tissue after a stroke. Fifteen patients with acute stroke involving medial cerebral artery occlusion were longitudinally explored with conventional and <jats:sup>23<\/jats:sup>Na MRI within 24\u2009h, 70\u2009h following stroke and at 3\u2009months to characterize the necrotic area. Time\u2010courses of sodium accumulations were observed within regions presenting with or spared by cytotoxic\/ionic edema and converting or not to necrosis. Dynamics of sodium accumulations were very different across subjects. At the group level, time\u2010courses of sodium signal in cytotoxic edema showed a non\u2010linear increase with an upper asymptote of 59\u2009\u00b1\u20096%% relative to the contralateral hemisphere. Regions with a larger early increase in <jats:sup>23<\/jats:sup>Na signal (ionic edema) showed a non\u2010linear accumulation during the first 70\u2009h and were associated with subsequent necrosis at month 3. Some of the regions with no ionic edema during the first 70\u2009h became necrotic at month 3, showing that pejorative pathophysiological processes could worsen after 70\u2009h following attack. Final necrotic volume was well predicted by the cytotoxic volume (ADC decrease) during the first 24\u2009h, and by the volume of ionic edema during the subacute period (25\u201370\u2009h) following attack. The regions showing ionic edema showed a non\u2010linear increase of <jats:sup>23<\/jats:sup>Na signal during the first 70\u2009h, with larger sodium accumulations in regions converting to necrosis at month 3. It may be of interest to consider the role of ionic edema imaging in the 70\u2009h after stroke and reperfusion, with a view to better understand stroke pathophysiology. Sodium MRI could add complementary information about the fate of cell necrosis within low ADC signal regions.<\/jats:p>","DOI":"10.1002\/nbm.70028","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T10:33:55Z","timestamp":1743762835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dynamics of Ionic and Cytotoxic Edema During Acute and Subacute Stages of Patients With Ischemic Stroke: Complementarity of <sup>23<\/sup>Na MRI and Diffusion MRI"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2500-1224","authenticated-orcid":false,"given":"Ma\u00ebva","family":"Cotinat","sequence":"first","affiliation":[{"name":"Aix Marseille Univ, CNRS, CRMBM  Marseille France"},{"name":"Aix Marseille Univ, APHM, Timone, CEMEREM  Marseille France"},{"name":"Physical and Rehabilitation Medicine Department Aix Marseille Univ, APHM, H\u00f4pitaux Sud  Marseille 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