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Therefore, we aimed to advance structural liver imaging at 7\u2009T by implementing a high\u2010resolution, phase\u2010shimmed, free\u2010breathing liver scan. Six healthy participants underwent liver MRI scans at 7\u2009T, utilizing an eight\u2010channel parallel transmission system for phase shimming. B<jats:sub>0<\/jats:sub> mapping and Fourier phase\u2010encoded dual refocusing echo acquisition mode (PE\u2010DREAM) multichannel B<jats:sub>1<\/jats:sub><jats:sup>+<\/jats:sup> mapping were performed during breath\u2010holds at expiration. Prospectively undersampled golden\u2010angle pseudo\u2010spiral k\u2010space data were acquired under free breathing, enabling retrospective respiratory binning using self\u2010gating. Post\u2010binning, the simultaneous autocalibrating and k\u2010space estimation (SAKE) algorithm was employed for interpolation of a center of k\u2010space area, prior to estimation of receive coil sensitivity maps. Image reconstruction was performed on expiration\u2010phase data using compressed sensing, optimizing image quality by evaluating various regularization factors and numbers of respiratory bins. Finally, N4BiasFieldCorrection was applied to the resulting images. Expiration\u2010phase image reconstruction using four bins and regularization factor values of 10<jats:sup>\u22122.5<\/jats:sup> (1.50\u2009mm) and 10<jats:sup>\u22122.33<\/jats:sup> (1.35\u2009mm) were found to optimize the tradeoff between sharpness, SNR, and artifacts. The optimized protocol facilitated clear visualization of the liver, blood vessels, and surrounding structures at isotropic resolutions of 1.50 and 1.35\u2009mm in 3.5\u2009min, without B<jats:sub>1<\/jats:sub><jats:sup>+<\/jats:sup> inhomogeneity effects in the shimmed liver region. A comparison between low\u2010resolution fully sampled free\u2010breathing (3.5\u2009min) and breath\u2010hold (19\u2009s) acquisitions demonstrated comparable sharpness and SNR. To compare the 7 T data with 3 T MRI, 3 T scans were performed for two participants. 3 T reconstructions were done similarly to 7 T, excluding N4BiasFieldCorrection. Scan\u2010specific regularization optimization was performed for fair comparison. Compared to 3\u2009T, 7\u2009T showed superior vascular contrast with inflow effects not observed at 3\u2009T. Fold\u2010over artifacts were present in 3\u2009T scans but were minor at 7\u2009T. 3 T and 7 T provided comparable results, with a much higher RF channel count at 3 T. In conclusion, high\u2010resolution expiration\u2010phase liver imaging at 7\u2009T with homogeneous signal can be successfully achieved using a phase\u2010shimmed, free\u2010breathing protocol with a golden\u2010angle pseudo\u2010spiral sampling pattern technique and respiratory self\u2010gating. This approach allows detailed anatomical depiction without the limitations of breath\u2010holding, representing a significant advancement in ultra\u2010high field abdominal MRI.\u00a0<\/jats:p>","DOI":"10.1002\/nbm.70047","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:50:22Z","timestamp":1745887822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Compressed Sensing\u2010Accelerated Free\u2010Breathing Liver MRI at 7\u2009T"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1063-9209","authenticated-orcid":false,"given":"Mitra","family":"Tavakkoli","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering McMaster University  Hamilton Ontario Canada"},{"name":"Imaging Research Centre St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5491-5379","authenticated-orcid":false,"given":"Bobby\u00a0A.","family":"Runderkamp","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8217-8192","authenticated-orcid":false,"given":"Matthijs\u00a0H.\u00a0S.","family":"de Buck","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center University of Amsterdam  Amsterdam the Netherlands"},{"name":"Spinoza Centre for Neuroimaging Royal Netherlands Academy for Arts and Sciences (KNAW)  Amsterdam the Netherlands"},{"name":"Computational and Cognitive Neuroscience and Neuroimaging Netherlands Institute for Neuroscience, KNAW  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6700-5058","authenticated-orcid":false,"given":"Gustav\u00a0J.","family":"Strijkers","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Physics, Amsterdam University Medical Center University of Amsterdam, Amsterdam Cardiovascular Sciences  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1464-159X","authenticated-orcid":false,"given":"Michael\u00a0D.","family":"Noseworthy","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering McMaster University  Hamilton Ontario Canada"},{"name":"Imaging Research Centre St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"},{"name":"Department of Medical Imaging McMaster University  Hamilton Ontario Canada"},{"name":"School of Biomedical Engineering McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5477-973X","authenticated-orcid":false,"given":"Aart\u00a0J.","family":"Nederveen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5162-8880","authenticated-orcid":false,"given":"Matthan\u00a0W.\u00a0A.","family":"Caan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Physics, Amsterdam University Medical Center University of Amsterdam, Amsterdam Cardiovascular Sciences  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3223-9721","authenticated-orcid":false,"given":"Wietske","family":"van der Zwaag","sequence":"additional","affiliation":[{"name":"Spinoza Centre for Neuroimaging Royal Netherlands Academy for Arts and Sciences (KNAW)  Amsterdam the Netherlands"},{"name":"Computational and Cognitive Neuroscience and Neuroimaging Netherlands Institute for Neuroscience, KNAW  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25677"},{"key":"e_1_2_9_3_1","first-page":"3","volume-title":"Advances in Magnetic Resonance Technology and Applications","author":"Runderkamp B. 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