{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T01:03:28Z","timestamp":1771290208895,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB024408"],"award-info":[{"award-number":["R01 EB024408"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS090417"],"award-info":[{"award-number":["R01NS090417"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The hippocampus is known to be a key site of pathology for dementia and epilepsy, consistent with its role in memory formation. With this brain region also known to be vulnerable to metabolic injury, spectroscopic studies of the hippocampus are of relevance. However, the hippocampus is a challenging region for measurement, given its irregular small size and the high susceptibility gradients (e.g., anterior vs. posterior, medial vs. lateral) in the human temporal lobe. We acquired single\u2010voxel spectra (3\u2009\u00d7\u20092\u2009\u00d7\u20091.2\u2009cm\n                    <jats:sup>3<\/jats:sup>\n                    encompassing the majority of the pes, body, and tail of the hippocampus) to separately measure the left and right hippocampi at 7\u2009T using advanced RF (transceiver array with RF shimming) and B\n                    <jats:sub>0<\/jats:sub>\n                    shimming methods (very high\u2010order shim insert).\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200915 healthy right\u2010handed middle\u2010aged subjects (age 47\u201368\u2009years) were recruited for this study. Based on the impact of the ApoE4 genotype on dementia risk, all subjects were genotyped as ApoE4 negative. The shim strategy resulted in equivalent Voigt linewidth (10.2\u2009\u00b1\u20092.9\u2009Hz and 10.9\u2009\u00b1\u20093.7\u2009Hz) and tCr SNR (27.2\u2009\u00b1\u20093.0 and 25.3\u2009\u00b1\u20094.6) for the left and right hippocampi, respectively, enabling direct comparisons. To further evaluate the spectra's accuracy for free creatine and phosphocreatine quantification, the data were fit with and without Gaussian broadening. This analysis showed that the original data shows no dependence of the creatine metabolites with the measured residual voxel field inhomogeneity\n                    <jats:italic>\u03c3<\/jats:italic>\n                    <jats:sub>B0<\/jats:sub>\n                    , whereas Gaussian broadening resulted in significant and undesirable changes in concentrations and statistically significant correlations with (the artificially broadened)\n                    <jats:italic>\u03c3<\/jats:italic>\n                    <jats:sub>B0<\/jats:sub>\n                    . The left hippocampus shows increased free creatine (3.3\u2009\u00b1\u20090.3\u2009mM vs. 2.8\u2009\u00b1\u20090.4\u2009mM\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and glutamine (2.3\u2009\u00b1\u20090.2\u2009mM vs. 2.0\u2009\u00b1\u20090.2\u2009mM,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) in comparison to the right. These two compounds were also found to be correlated in the left (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.35\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), but not in the right hippocampus. These results show that with advanced methods, 7\u2009T spectroscopy detects neurometabolic differences between the hippocampi.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70072","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T20:24:18Z","timestamp":1749068658000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asymmetric Hippocampal Metabolism Evaluated by Single\u2010Voxel Spectroscopy at 7\u2009T"],"prefix":"10.1002","volume":"38","author":[{"given":"F.","family":"Paladi","sequence":"first","affiliation":[{"name":"Department of Radiology University of Missouri Columbia  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Computer Science University of Nebraska Omaha  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u00a0P.","family":"Hetherington","sequence":"additional","affiliation":[{"name":"Resonance Research Inc  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.\u00a0J.","family":"Terpstra","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Missouri Columbia  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.\u00a0L.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Missouri Columbia  Columbia Missouri USA"},{"name":"Department of Bioinformatics University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u00a0W.","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Missouri Columbia  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00179"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.025"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3308"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa219"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2019.06.005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1987.tb01001.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.137"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3836"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.07.084"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.199.2.8668782"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2015.55710"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910290613"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.5021"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4197"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199904)41:4<649::AID-MRM2>3.0.CO;2-G"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03166960"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30412-9"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.630502"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.5146"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24122"},{"key":"e_1_2_10_23_1","unstructured":"H. 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