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It is highly desirable to develop novel MRI sequences to image bone, providing a radiation\u2010free modality for skeletal imaging. We compared the morphological and quantitative strength of three\u2010dimensional (3D) ultrashort echo time (UTE), zero echo time (ZTE), and short TR adiabatic inversion recovery UTE (STAIR\u2010UTE) MRI techniques for bone imaging in various skeletal anatomical regions, including the forearm, wrist, lower leg, upper leg, and skull. Five healthy volunteers (four male and one female) were subject to four MRI sequences, including 3D UTE with 2\u00b0 and 7\u00b0 flip angles (FAs), 3D ZTE with 2\u00b0 FA, and 3D STAIR\u2010UTE with 14\u00b0 FA. Regions of interest (ROIs) were drawn in cortical bone, marrow cavity, and muscle to measure their signal intensities. An artifact\u2010free ROI was also placed in the image background to measure the standard deviation (SD) of noise. The signal\u2010to\u2010noise ratio of bone (SNR<jats:sub>Bone<\/jats:sub>) and contrast\u2010to\u2010noise ratios (CNRs) between bone and marrow (CNR<jats:sub>Bone\u2010Marrow<\/jats:sub>) and bone and muscle (CNR<jats:sub>Bone\u2010Muscle<\/jats:sub>) were measured in different anatomical regions. These SNR and CNRs were divided by the square root of acquisition time. In addition, bone volume renderings were generated from 3D STAIR\u2010UTE images. The averages and SDs of SNR<jats:sub>Bone<\/jats:sub>, CNR<jats:sub>Bone\u2010Marrow<\/jats:sub>, and CNR<jats:sub>Bone\u2010Muscle<\/jats:sub> were calculated for different anatomical regions. UTE with 7\u00b0 FA has the highest positive SNR and negative CNR. UTE and ZTE sequences with the same FAs of 2\u00b0 have similar SNR and CNR values. The STAIR\u2010UTE sequence with 14\u00b0 FA has the lowest SNR but is the only sequence providing positive CNR for bone at all investigated body regions, which can be used for direct bone volume rendering. The STAIR\u2010UTE technique provides high contrast volumetric imaging of skeletal anatomies, which enables us to generate direct bone surface\u2010rendered images in clinically acceptable scan time.<\/jats:p>","DOI":"10.1002\/nbm.70102","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T01:19:14Z","timestamp":1752628754000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fast Volumetric Imaging of Bone Using a Three\u2010Dimensional Short TR Adiabatic Inversion Recovery Ultrashort Echo Time (STAIR\u2010UTE) Sequence"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5601-6392","authenticated-orcid":false,"given":"Mahyar","family":"Daskareh","sequence":"first","affiliation":[{"name":"Department of Radiology University of California  San Diego California 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