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Single\u2010layer Ti<jats:sub>3<\/jats:sub>C<jats:sub>2<\/jats:sub> was synthesized via the HCL\/LiF etching technique, with the flake size subsequently tailored and the hydroxylated surface modified through a hydrothermal process. Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> nanoparticles and MnO<jats:sub>2<\/jats:sub> nanosheets were integrated onto the two\u2010dimensional Ti<jats:sub>3<\/jats:sub>C<jats:sub>2<\/jats:sub>\u2010MXene surface using an in\u00a0situ doping approach, and the final modification was achieved with carboxymethyl chitosan. Various characterization techniques were employed to assess the physical and chemical properties of the probe, which were then combined with a CEST contrast agent to investigate the mechanisms of multimodal magnetic resonance imaging and in\u00a0vitro photothermal effects. Upon integrating the multi\u2010modal molecular probe with Ioversol for imaging purposes, at a magnetic field strength of B<jats:sub>1<\/jats:sub>\u2009=\u20091.25 \u03bcT and with a molecular probe concentration of 0.5\u2009mg\/mL, the CEST signal from Ioversol is almost entirely suppressed. This allows for the successful identification of a distinct concentration range where both contrast agents can coexist. In\u00a0vitro photothermal studies on MXene codoped with iron and manganese have shown that the composite molecular probe exhibits excellent photothermal efficiency. The method combining complex nanoprobes with CEST contrast agents successfully achieved simultaneous imaging of both contrast agents. In\u00a0vitro MRI experiments successfully obtained distinguishable concentration ranges for both, with changes in CEST signals reflecting the concentration variations of the complex molecular probes, which also exhibit good photothermal therapy (PTT) capabilities.<\/jats:p>","DOI":"10.1002\/nbm.70116","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T11:45:36Z","timestamp":1754739936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preparation of Fe\u2013Mn Codoped 2D MXene Nanoprobes and Feasibility Study of Combining With CEST for Multimodal Imaging"],"prefix":"10.1002","volume":"38","author":[{"given":"Fei\u2010Xiang","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Radiology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College, Fudan University  Shanghai 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