{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:18:06Z","timestamp":1785388686678,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Breast density is a recognized risk factor for breast cancer and can affect the sensitivity of mammography. Consequently, magnetic resonance imaging (MRI) is recommended as a screening modality for women with increased breast density. However, mammography remains the primary method for assessing a woman's breast density classification. magnetic resonance elastography (MRE) is a new technique to evaluate tissue stiffness characteristics. This study aims to evaluate the ability of MRE to distinguish between fibroglandular and fatty tissues in normal women with different breast densities, potentially aiding in the classification of breast density using MRI. Forty\u2010three women aged 40\u201379\u2009years with normal screening mammograms were included in this prospective study. MRE was performed using a 1.5\u2010T MRI scanner, and an in\u2010house passive driver was used to obtain an MRE\u2010capable gradient echo (GRE) sequence, which was integrated into a noncontrast\u2010enhanced breast MRI protocol. MRE images were analyzed to measure stiffness values for fibroglandular and fatty tissue based on regions of interest (ROIs) in both breasts. Differences in mean stiffness between tissue types were assessed; a <jats:italic>p<\/jats:italic>\u2010value &lt;\u20090.05 was considered significant. Fibroglandular tissue exhibited significantly higher stiffness than fatty tissue in both breasts (right breast: 1.55\u2009\u00b1\u20090.31\u2009kPa vs. 0.82\u2009\u00b1\u20090.13\u2009kPa, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; left breast: 1.46\u2009\u00b1\u20090.23\u2009kPa vs. 0.81\u2009\u00b1\u20090.11\u2009kPa, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Comparison between dense and nondense groups on mammograms revealed no significant difference in stiffness for the same tissue types in both breasts. MRE can potentially differentiate between fibroglandular and fatty breast tissues based on shear stiffness, independent of mammographic density. Future research with larger cohorts, including cancer cases, is needed to further establish MRE's role in breast cancer screening.<\/jats:p>","DOI":"10.1002\/nbm.70134","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T06:44:16Z","timestamp":1756709056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Differentiating Breast Tissue Stiffness With Magnetic Resonance Elastography (MRE): A Focus on Fibroglandular and Fatty Tissues"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-6378","authenticated-orcid":false,"given":"Areej\u00a0S.","family":"Aloufi","sequence":"first","affiliation":[{"name":"Radiological Sciences Department, College of Applied Medical Sciences King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah\u00a0H.","family":"Abujamea","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1185-8067","authenticated-orcid":false,"given":"Faisal\u00a0S.","family":"Fakhouri","sequence":"additional","affiliation":[{"name":"Department of Biomedical Technology, College of Applied Medical Sciences King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman\u00a0M.","family":"Albeshan","sequence":"additional","affiliation":[{"name":"Radiological Sciences Department, College of Applied Medical Sciences King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora\u00a0A.","family":"Alohaly","sequence":"additional","affiliation":[{"name":"Radiological Sciences Department, College of Applied Medical Sciences King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem\u00a0A.","family":"Sabir","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer\u00a0M.","family":"Aldawsari","sequence":"additional","affiliation":[{"name":"Radiological Sciences Department, College of Applied Medical Sciences King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reham\u00a0S.","family":"Altokhais","sequence":"additional","affiliation":[{"name":"Radiological Sciences Department, College of Applied Medical Sciences King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehreen\u00a0A.","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1495-6882","authenticated-orcid":false,"given":"Ashwag\u00a0R.","family":"Alruwaili","sequence":"additional","affiliation":[{"name":"Radiological Sciences Department, College of Applied Medical Sciences King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062790"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0034"},{"key":"e_1_2_10_4_1","volume-title":"Breast Imaging Reporting and Data System (BI\u2010RADS). 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