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Deuterium metabolic imaging (DMI) is a novel, noninvasive technique for mapping tissue\u2010specific uptake and metabolism of deuterium\u2010labeled tracers. This study evaluates the feasibility of renal DMI at 7\u2010Tesla (7T) to track deuterium\u2010labeled tracers with high spatial and temporal resolution, aiming to establish a foundation for potential clinical applications in the noninvasive investigation of renal physiology and pathophysiology. Five healthy participants (3\u2009m\/2f) underwent renal DMI at 7T using MR spectroscopic imaging with concentric ring trajectory sampling. Two subjects participated in dynamic DMI experiments after oral administration of deuterium\u2010labeled water (D<jats:sub>2<\/jats:sub>O, 0.25, and 0.5\u2009mL\/kg) or glucose ([6,6\u2032\u2010<jats:sup>2<\/jats:sup>H]\u2010Glc, 0.5\u2009g\/kg) following 12\u2009h overnight fasting. Continuous glucose monitoring (CGM) was performed using FreeStyle Libre 3 and compared to renal <jats:sup>2<\/jats:sup>H\u2010glucose levels. Three\u2010dimensional maps of <jats:sup>2<\/jats:sup>H\u2010water and <jats:sup>2<\/jats:sup>H\u2010glucose were acquired every \u223c8.5\u2009min at isotropic resolutions of \u223c1.8 and \u223c0.9\u2009mL, respectively. Tensor Marchenko\u2010Pastur Principal Component Analysis (tMPPCA) was used for spectral denoising. Renal DMI successfully generated dynamic 3D maps of <jats:sup>2<\/jats:sup>H\u2010water and <jats:sup>2<\/jats:sup>H\u2010glucose with improved spatial resolution compared to previous studies. Following D<jats:sub>2<\/jats:sub>O ingestion, <jats:sup>2<\/jats:sup>H\u2010water dynamics (0\u201060\u2009min) and steady\u2010state levels (&gt;\u200990\u2009min) were assessed. Following <jats:sup>2<\/jats:sup>H\u2010glucose ingestion, renal <jats:sup>2<\/jats:sup>H\u2010Glc concentrations peaked at 1.8\u2009\u00b1\u20091.0\u2009mM on average over both kidneys, and overall dynamics aligned with interstitial glucose levels simultaneously assessed using CGM sensor. This study demonstrates the feasibility of dynamic renal DMI with improved spatial resolution to noninvasively map multiple <jats:sup>2<\/jats:sup>H\u2010labeled tracers in the human kidney at 7T. Future improvements in signal mitigation and intravenous tracer administration could enhance its clinical utility, potentially aiding in the evaluation of metabolic effects of novel therapies like SGLT\u20102 inhibitors for personalized treatment strategies.<\/jats:p>","DOI":"10.1002\/nbm.70139","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T12:28:01Z","timestamp":1757420881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Feasibility of High\u2010Resolution Deuterium Metabolic Imaging of the Human Kidney Using Concentric Ring Trajectory Sampling at 7T"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1235-7595","authenticated-orcid":false,"given":"Fabian","family":"Niess","sequence":"first","affiliation":[{"name":"High\u2010Field MR Center, Department of Biomedical Imaging and Image\u2010Guided Therapy Medical University of Vienna  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