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Developing noninvasive imaging techniques to assess ChP is crucial for studying its function and age\u2010related neurofluid dynamics. In this study, we developed a relaxation\u2010selective intravoxel incoherent motion (IVIM) technique to assess tissue and fluid compartments in the ChP of 83 middle\u2010aged to elderly participants (age: 61.5\u2009\u00b1\u200917.1\u2009years) and 15 young controls (age: 30.7\u2009\u00b1\u20092.9\u2009years). Using a 3\u2010T MRI scanner, we implemented T1\u2010 and T2\u2010selective IVIM approaches, including Fluid\u2010Attenuated Inversion Recovery IVIM (FLAIR\u2010IVIM), LongTE\u2010IVIM, and Vascular Space Occupancy\u2010LongTE\u2010IVIM (VASO\u2010LongTE\u2010IVIM), to measure diffusivity and volume fractions of fluid compartments in ChP. Our results showed that FLAIR\u2010IVIM identified an additional interstitial fluid (ISF) compartment with free\u2010water\u2010like diffusivity in ChP. We then evaluated the aging effects on microvascular perfusion and ISF in ChP. Compared to younger adults, older adults exhibited increased ChP volume, reduced perfusion, decreased ISF volume fraction, and lower tissue diffusivity. Relaxation\u2010selective IVIM may offer enhanced specificity for characterizing age\u2010related changes in ChP structure and fluid dynamics.<\/jats:p>","DOI":"10.1002\/nbm.70144","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:39:21Z","timestamp":1757767161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Relaxation\u2010Selective Intravoxel Incoherent Motion Imaging of Microvascular Perfusion and Fluid Compartments in the Human Choroid Plexus"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4244-8615","authenticated-orcid":false,"given":"Chenyang","family":"Li","sequence":"first","affiliation":[{"name":"Center for Biomedical Imaging, Department of Radiology NYU Grossman School of Medicine  New York New York 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