{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T06:11:03Z","timestamp":1760940663563,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013373","name":"NIHR Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Quantitative MRI markers of the liver are attractive diagnostic tools of metabolic dysfunction\u2010associated steatotic liver disease (MASLD). However,  measurements are confounded by physiological factors, such as hydration. The aim of this study is to evaluate the dynamic effects of hydration with isotonic drinks on quantitative MRI measurements of the liver in healthy male individuals. Shortened modified Look\u2010Locker inversion recovery\u2010based (shMOLLI) , , proton density fat fraction (PDFF), apparent diffusion coefficient (ADC), stiffness, and volume of the liver, as well as shMOLLI  and volume of the spleen were measured repeatedly in six healthy male volunteers at 3\u2009T after ingesting 0.5, 1.0, and 1.5\u2009L of isotonic drink on three different days.  data were fitted to a first\u2010order linear time\u2010invariant system model, descriptive statistics were calculated for the other parameters, and linear mixed models were employed to assess co\u2010variates of quantitative MRI parameters. Liver  showed a maximum absolute increase of 58, 60, and 90\u2009ms, while spleen  showed a maximum absolute increase of 45, 70, and 150\u2009ms corresponding to 0.5, 1.0, and 1.5\u2009L of isotonic drink, respectively. The maximum change in ADC, , liver volume and spleen volume gradually increased, while that in liver stiffness gradually decreased with increasing amounts of isotonic drinks. PDFF values had no dependence on the volume of ingested isotonic drink. First\u2010order models showed increasing time constants for both the liver and the spleen corresponding to increasing isotonic drink volumes. Liver time constants were only dependent on ingested drink volume. This study explored the effect of different volumes of isotonic drink and quantitative liver MRI markers. We found that the increase in  likely bears clinical significance, however, the variation observed in the other parameters need further investigation and validation in a larger cohort.<\/jats:p>","DOI":"10.1002\/nbm.70156","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:41:18Z","timestamp":1759992078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the Effect of Isotonic Drinks on Quantitative MRI Markers of the Liver and Spleen"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5155-7540","authenticated-orcid":false,"given":"Natassa\u00a0N.","family":"Pittas","sequence":"first","affiliation":[{"name":"Department of Oncology University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Pavlides","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine University of Oxford  Oxford UK"},{"name":"Translational Gastroenterology Unit University of Oxford  Oxford UK"},{"name":"Oxford NIHR Biomedical Research Centre Oxford University Hospitals NHS Foundation Trust and the University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc\u00a0E.","family":"M\u00f3zes","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0431"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0104-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.171"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4530"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.09.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323188"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9112458"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2334-8525"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25392"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25146"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24867"},{"key":"e_1_2_9_14_1","unstructured":"F. 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