{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T07:35:43Z","timestamp":1764747343741,"version":"3.46.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:00:00Z","timestamp":1762041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["NIH\u2010R21\u2010TR003033"],"award-info":[{"award-number":["NIH\u2010R21\u2010TR003033"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Parsonage\u2013Turner syndrome (PTS) is a spontaneous neuropathy characterized by severe upper extremity pain and muscle denervation and is considered to be a rare disease that is under\u2010recognized. Quantitative MRI (qMRI) characterizes muscle denervation but has not been previously assessed in a longitudinal PTS cohort. The aims of this study are to prospectively and longitudinally characterize qMRI changes in PTS patients at baseline (&lt;\u20096\u2009months' symptom onset) and at follow\u2010up timepoints (3, 6, and 12\u2009months), to measure associations against electromyography (EMG) and muscle strength, and to predict muscle strength at follow\u2010up. A total of 49 subjects (age\u2009=\u200947.2\u2009\u00b1\u200914.0\u2009years, 31\u2009M\/18 F) underwent 3\u2010Tesla qMRI with T2\u2010mapping, diffusion\u2010based muscle fiber diameter, volumetry, and fat fraction (FF) mapping. Image segmentation of involved muscles was performed by two raters. Linear regression between qMRI metrics and days from symptom onset (DSO) was performed. Pearson's correlation quantified correlations between qMRI metrics, and Kendall's tau assessed correlations between qMRI and EMG and muscle strength. For predictive modeling of muscle strength, a generalized linear model was used, and the coefficient of determination (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    ) was compared for combinations of baseline inputs. Regression detected a mean T2 increase of 0.66\u2009ms\/week and a mean muscle fiber diameter decrease of 0.96\u2009\u03bcm\/week within DSO of 100. Muscle fiber diameter correlated with muscle volume (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.850). T2 correlated with EMG (|\n                    <jats:italic>\u03c4<\/jats:italic>\n                    |\u2009=\u20090.34\u20130.78) and muscle strength (|\n                    <jats:italic>\u03c4<\/jats:italic>\n                    |\u2009=\u20090.40\u20130.83) in most muscles that could be analyzed. Muscle fiber diameter was correlated to EMG (|\n                    <jats:italic>\u03c4<\/jats:italic>\n                    |\u2009=\u20090.43\u20130.72) and muscle strength in some muscles (|\n                    <jats:italic>\u03c4<\/jats:italic>\n                    |\u2009=\u20090.39\u20130.56). The addition of baseline T2 values improved the prediction of muscle strength at 3\u2010month (from\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.57 to 0.67, with \u22120.057 to \u22120.068 muscle grade per ms T2), at 6\u2010month (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.40\u20130.59, \u22120.057 to \u22120.071 grade per ms), and at 12\u2010month follow\u2010up (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.40\u20130.62, \u22120.053 to \u22120.080 grade per ms).\n                  <\/jats:p>\n                  <jats:p>Muscle qMRI measurements in PTS depict muscle denervation and provide complementary characterization of muscle quality for diagnosis and follow\u2010up assessment.<\/jats:p>","DOI":"10.1002\/nbm.70172","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:05:02Z","timestamp":1762142702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative MRI of Muscle Denervation in Subacute Parsonage\u2013Turner Syndrome: A Prospective, Longitudinal Study"],"prefix":"10.1002","volume":"38","author":[{"given":"Ek\u00a0T.","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Radiology and Imaging Hospital for Special Surgery  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim\u00a0Y.","family":"Li","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yenpo","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Hospital for Special Surgery  New York New York USA"},{"name":"Department of Medical Imaging and Intervention Chang Gung Memorial Hospital  Taoyuan City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gracyn\u00a0J.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Hospital for Special Surgery  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Akerman","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Hospital for Special Surgery  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9779-3348","authenticated-orcid":false,"given":"Shayna\u00a0E.","family":"Turbin","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Hospital for Special Surgery  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph\u00a0H.","family":"Feinberg","sequence":"additional","affiliation":[{"name":"Department of Physiatry Hospital for Special Surgery  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo\u00a0J.","family":"Milani","sequence":"additional","affiliation":[{"name":"Department of Physiatry Hospital for Special Surgery  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiril","family":"Kiprovski","sequence":"additional","affiliation":[{"name":"Department of Neurology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darryl\u00a0B.","family":"Sneag","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Hospital for Special Surgery  New York New York 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