{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:51:40Z","timestamp":1778327500791,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR078877"],"award-info":[{"award-number":["R01AR078877"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG072972"],"award-info":[{"award-number":["P30AG072972"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SE 3272\/1\u20101"],"award-info":[{"award-number":["SE 3272\/1\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SE3272\/6\u20101"],"award-info":[{"award-number":["SE3272\/6\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To evaluate the feasibility of diffusion tensor imaging (DTI) using quantitative ultrashort echo time double\u2010echo steady\u2010state (qUTE\u2010DESS) MRI in short\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>2<\/jats:italic>\n                    <\/jats:sub>\n                    musculoskeletal tissues, we validated it in phantoms, an ex\u00a0vivo porcine hoof, and an in\u00a0vivo human knee. The qUTE\u2010DESS sequence was implemented on a clinical 3\u2009T MRI system, enabling simultaneous estimation of\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>1<\/jats:italic>\n                    <\/jats:sub>\n                    ,\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>2<\/jats:italic>\n                    <\/jats:sub>\n                    , and diffusivity in tissues with rapid signal decay. Data were acquired with six diffusion\u2010weighting orientations (x, y, z, xy, yz, xz) to obtain mean diffusivity (MD) and fractional anisotropy (FA). Sucrose and agarose phantoms demonstrated linear relationships between\n                    <jats:italic>\n                      T\n                      <jats:sub>1<\/jats:sub>\n                    <\/jats:italic>\n                    ,\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>2<\/jats:italic>\n                    <\/jats:sub>\n                    , or diffusivity and their concentrations (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009&gt; 0.88). A celery phantom demonstrated anisotropic diffusion by revealing elevated FA in fibrous structures. In experiments with the porcine hoof and healthy volunteers' knees, qUTE\u2010DESS generated high\u2010resolution parameter maps of MD and FA across various tissues, including cartilage, meniscus, tendon, ligament, and muscle, effectively capturing short\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>2<\/jats:italic>\n                    <\/jats:sub>\n                    components that conventional DTI could not visualize. By preserving ultrashort echo signals, qUTE\u2010DESS appeared to overcome the limitations of spin\u2010echo\u2013based DTI, which suffers from longer echo times and subsequent signal loss in short\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>2<\/jats:italic>\n                    <\/jats:sub>\n                    tissues. Therefore, this approach may serve as a valuable quantitative imaging tool for assessing microstructural features in the musculoskeletal system, facilitating detection and evaluation of joint abnormalities or degenerative changes. The results suggest qUTE\u2010DESS can provide insight into both long and short\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>2<\/jats:italic>\n                    <\/jats:sub>\n                    tissues, offering potential benefits in clinical diagnosis and research. Further studies should assess its diagnostic utility in larger cohorts with musculoskeletal pathologies.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70184","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T04:24:31Z","timestamp":1764563071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diffusion Tensor Imaging of Short\n                    <i>T<\/i>\n                    <sub>2<\/sub>\n                    Tissues Using Quantitative Ultrashort Echo Time Double\u2010Echo Steady\u2010State: A Feasibility Study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8763-4799","authenticated-orcid":false,"given":"Jinil","family":"Park","sequence":"first","affiliation":[{"name":"Department of Radiology University of California, Davis  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eddie","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California, Davis  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngkyoo","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California, Davis  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Nardo","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California, Davis  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhijit\u00a0J.","family":"Chaudhari","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California, Davis  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5755-9951","authenticated-orcid":false,"given":"Heejung","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of California, Davis  Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyungseok","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California, Davis  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728\u2010200311000\u201000001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24713"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/crad.2003.1157"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2010.11.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20851"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.220029"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2006.05.014"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520946772"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256\u2010022\u201004269\u20101"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbmr\/zjae053"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22474"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.10.018"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25999"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28388"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2017.07.012"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.10.002"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology9080194"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24129841"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.07.012"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102004\u2010861764"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24437"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1208"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13189"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.01.013"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.188.1.8511302"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1076\u20106332(98)80264\u2010X"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2013.00031"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41747\u2010017\u20100018\u20101"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010023\u201003420\u2010w"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.03.002"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1114\/1.1581879"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24767"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880060212"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22036"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841850902849444"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018\u2010015\u20100326\u20101"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26577"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28769"},{"key":"e_1_2_10_40_1","unstructured":"H.Jang Y.Ma A.Masoud\u2010Afsahi et\u00a0al. \u201cQuantitative UTE Double Echo Steady State (qUTE\u2010DESS) for Simultaneous Mapping ofT1 T2 and Diffusivity of ShortT2Tissues \u2013 Ex\u00a0Vivo study \u201d Joint Annual Meeting ISMRM\u2010ESMRMB & ISMRT 31st Annual Meeting (2022) 1411 https:\/\/cds.ismrm.org\/protected\/22MProceedings\/PDFfiles\/1411.html."},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4939"},{"key":"e_1_2_10_42_1","unstructured":"H.Jang S. H.Shin D.Moazamian et\u00a0al. \u201cQuantitative Ultrashort Echo Time Double Echo Steady State (qUTE\u2010DESS) forT1 T2 and Diffusivity Mapping of Human Cartilage. Joint Annual Meeting ISMRM\u2010ESMRMB & ISMRT 33rd Annual Meeting (2024) 2261https:\/\/cds.ismrm.org\/protected\/24MProceedings\/PDFfiles\/2261_LjiMkqRBk.html"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1389859"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23275"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1695690"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971\u20103026.38505"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110821"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2004.11.018"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25988"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/s22197459"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27066"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.70184","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nbm.70184","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.70184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:14:51Z","timestamp":1772961291000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.70184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,30]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/nbm.70184"],"URL":"https:\/\/doi.org\/10.1002\/nbm.70184","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,30]]},"assertion":[{"value":"2025-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70184"}}