{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:36Z","timestamp":1786978296032,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG081932"],"award-info":[{"award-number":["R01 AG081932"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 EB031771"],"award-info":[{"award-number":["P41 EB031771"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Longitudinal (\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    ) and transverse (\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    ) relaxation times measured by MRI are promising markers for assessing biological processes and disease pathology. In this study, we characterized the\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    and\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    relaxation times in the Tg2576 mouse model of Alzheimer's disease (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200910) across ten time points, ranging from 3 to 14\u2009months of age, using an 11.7\u2009T MRI scanner. Genotype\u2010dependent changes over time were observed in the thalamus, hypothalamus, and piriform cortex, suggesting that the rates of change in relaxation times within these regions may serve as potential markers for distinguishing Tg2576 mice from their wildtype (WT) counterparts. In addition, significant genotype differences were detected in the isocortex and hippocampus. These observations likely reflect the interplay between changes in tissue water content and the accumulation of amyloid plaques. To provide a reference for future MRI studies, we also calculated the average relaxation times over time points for WT mice. The mean\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    values were 2036.3\u2009\u00b1\u200926.8\u2009ms (isocortex), 2046.5\u2009\u00b1\u200928.7\u2009ms (hippocampus), 1861.7\u2009\u00b1\u200922.2\u2009ms (thalamus), 1897.8\u2009\u00b1\u200957.0\u2009ms (hypothalamus), and 2099.7\u2009\u00b1\u200930.5\u2009ms (piriform cortex). Corresponding\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    values were 38.3\u2009\u00b1\u20090.5\u2009ms (isocortex), 39.0\u2009\u00b1\u20090.2\u2009ms (hippocampus), 35.4\u2009\u00b1\u20090.3\u2009ms (thalamus), 36.9\u2009\u00b1\u20090.4\u2009ms (hypothalamus), and 40.3\u2009\u00b1\u20090.3\u2009ms (piriform cortex).\n                  <\/jats:p>","DOI":"10.1002\/nbm.70187","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:45:33Z","timestamp":1763685933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Longitudinal MRI Characterization of\n                    <i>T<\/i>\n                    <sub>1<\/sub>\n                    and\n                    <i>T<\/i>\n                    <sub>2<\/sub>\n                    Relaxation Times in an Amyloid Mouse Model of Alzheimer's Disease at 11.7\u2009T"],"prefix":"10.1002","volume":"39","author":[{"given":"Soven","family":"Kumar","sequence":"first","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Yang","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguo","family":"Li","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"F. M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Research Institute  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Bibic","sequence":"additional","affiliation":[{"name":"F. M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Research Institute  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8477-2440","authenticated-orcid":false,"given":"Zhiliang","family":"Wei","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"F. M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Research Institute  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.150.1.6689792"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2018.05.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.974651"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25198"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118214"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1163"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/BSI-190185"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2010.07.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.rev.2024-0013"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25197"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20285"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22022"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-013-0378-3"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-011-0287-2"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2016.12.012"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4207"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.10.058"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.53941\/hm.2025.100009"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5284.99"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mex.2025.103175"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.10.058"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145255"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mex.2025.103306"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.09.005"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21334"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105493"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2009.06.022"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098143"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3RU0816-352RR"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.11.023"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3407"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119144"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.661838"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-020-00230-3"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-3-5"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S503231"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12049"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(02)00070-0"},{"key":"e_1_2_10_40_1","first-page":"31","article-title":"A\u03b2 Plaques","volume":"1","author":"Walker L. C.","year":"2020","journal-title":"Free Neuropathology"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20675"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205012666151027123728"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2018.03.010"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28433"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.02.071"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10371"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21313"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24533"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0281-2"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4568"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106711"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00559"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4377"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-021-01432-9"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27708"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.70187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nbm.70187","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.70187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:14:42Z","timestamp":1772961282000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.70187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/nbm.70187"],"URL":"https:\/\/doi.org\/10.1002\/nbm.70187","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"assertion":[{"value":"2025-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70187"}}