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Magnetic resonance imaging (MRI) offers non\u2010invasive, quantitative assessment of tissue perfusion and microstructure. This study demonstrates the feasibility of acquiring high\u2010resolution MRI sequences from porcine livers undergoing ex\u00a0vivo perfusion using a custom MRI\u2010compatible rig. Seven porcine livers were retrieved from the abattoir and perfused with oxygenated autologous blood inside a 3\u2009T clinical MRI scanner. MRI sequences acquired included T2\u2010weighted imaging, diffusion weighted imaging (DWI) and Dynamic Contrast Enhanced (DCE) imaging following gadolinium injection into the portal vein and hepatic artery. Histological assessment was performed to evaluate preservation injury, with comparison to static cold storage (SCS) controls. MRI during perfusion enabled dynamic measurement of tissue perfusion, including generation of gadolinium enhancement curves and apparent diffusion coefficient (ADC) maps. Vascular segmentation down to 0.45\u2009mm resolution allowed quantification of morphological features such as vessel tortuosity. Histological analysis demonstrated superior preservation in perfused livers compared to SCS. This platform enables detailed, quantitative evaluation of vascular morphology and flow in whole organs, with translational relevance for modelling vascular disease and evaluating targeted drug\u2010delivery strategies.<\/jats:p>","DOI":"10.1002\/nbm.70236","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:50:43Z","timestamp":1770436243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real Time Evaluation of Whole Organ Perfusion by Magnetic Resonance Imaging in Ex\u00a0Vivo Machine\u2010Perfused Liver"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6799-0585","authenticated-orcid":false,"given":"Zainab\u00a0L.","family":"Rai","sequence":"first","affiliation":[{"name":"Royal Free Hospital London NHS Foundation Trust  London UK"},{"name":"Centre for Surgical Innovation, Organ Regeneration and Transplantation (CSIORT), Division of Surgery 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