{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:27:06Z","timestamp":1790954826910,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018703","name":"HORIZON EUROPE European Innovation Council","doi-asserted-by":"publisher","award":["101058229"],"award-info":[{"award-number":["101058229"]}],"id":[{"id":"10.13039\/100018703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Phosphorus\u201031 magnetic resonance spectroscopy (\n 31<\/jats:sup>\n P\u2010MRS) can be used to characterize the steady\u2010state in\u00a0vivo myocardial energy status via the phosphocreatine (PCr) over adenosine triphosphate (ATP) tissue concentration ratio. Although used in many studies, this modality suffers from low sensitivity and poor measurement precision. This work reports on the acquisition of\n 31<\/jats:sup>\n P\u2010MR spectra of the in\u00a0vivo human heart using a 7\u2009T MR system equipped with an integrated whole\u2010body RF transmit coil for\n 31<\/jats:sup>\n P spin excitation. Eight volunteers (male\/female,\n n<\/jats:italic>\n \u2009=\u20094\/4) underwent\n 31<\/jats:sup>\n P\u2010MRS at 7\u2009T twice, using a low\u2010flip angle, short\u2010repetition time 3D\n 31<\/jats:sup>\n P\u2010MR spectroscopic imaging sequence with a 20\u2010mm isotropic resolution and a 21\u2010min acquisition time. A 16\u2010channel\n 31<\/jats:sup>\n P receive array was used for signal reception. Myocardial voxels were identified on transversal cine proton MR images. Signals of PCr, phosphodiesters (PDE), and inorganic phosphate (P\n i<\/jats:sub>\n ) were quantified relative to ATP and corrected for partial saturation and blood signal contamination. Bland\u2013Altman analyses were used to establish intersession measurement repeatability. A comparison of supine and prone positioning was made for two subjects, yielding similar results but superior comfort for lying supine. Mid\u2010septal myocardial PCr\/ATP was 1.85\u2009\u00b1\u20090.37, with a repeatability coefficient of 17.7%. The repeatability coefficients for P\n i<\/jats:sub>\n \/ATP and PDE\/ATP were 142.7% and 51.6%, respectively. Using the spatially homogeneous\n 31<\/jats:sup>\n P spin excitation with the integrated whole\u2010body RF transmit coil, we made quantitative estimates of the myocardial energy status at a higher precision than previously achieved at lower main magnetic field strengths. The noninvasive nature and high precision of the presented\n 31<\/jats:sup>\n P\u2010MR spectroscopic imaging approach will allow for therapeutic efficacy monitoring with repeated measurements in longitudinal study designs and investigations of normal physiology in healthy volunteers.\n <\/jats:p>","DOI":"10.1002\/nbm.70248","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T07:21:52Z","timestamp":1771572112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["31<\/sup>\n P\u2010MRS of the Human Heart at 7\u2009T With an Integrated Whole\u2010Body\n 31<\/sup>\n P Radiofrequency Transmit Coil"],"prefix":"10.1002","volume":"39","author":[{"given":"Mark\u00a0W.\u00a0J.\u00a0M.","family":"Gosselink","sequence":"first","affiliation":[{"name":"Department of Radiology University Medical Center Utrecht Utrecht the 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