{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:30:17Z","timestamp":1773923417960,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Placental insufficiency is a major cause of preeclampsia and fetal growth restriction. The reduced uterine perfusion pressure (RUPP) rat model reproduces cardinal features of these disorders, but longitudinal changes in placental perfusion after RUPP are poorly documented. This study aimed to assess the acute and late effects of RUPP on placental perfusion between gestational day (GD) 14 and GD18 using 3D dynamic contrast\u2010enhanced magnetic resonance imaging (3D\u2010DCE MRI). Pregnant Sprague Dawley rats (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200931) were randomized to RUPP or normal pregnant (NP) groups on GD14. 3D\u2010DCE MRI scans were performed on GD14, GD15, and GD16 or GD18. Perfusion parameters, including time to peak (TTP), maximum enhancement (ME), wash\u2010out percentage (WO%), initial area under the curve (iAUC), and total area under the curve (AUC), were derived from fitted signal\u2013time curves. In addition, exploratory voxel\u2010wise histogram analysis was performed to assess intralitter variability. At GD14, RUPP placentas showed delayed TTP (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), reduced ME (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03), reduced WO% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), and elevated iAUC (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). Differences persisted for TTP (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02) and WO% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01) at GD15 but resolved by GD16\u2013GD18. Voxel\u2010wise analysis revealed intralitter heterogeneity, with 20% of analyzed RUPP placentas deviating from the NP template. These findings indicate that RUPP induces an acute but transient impairment of placental perfusion, with recovery by late gestation. GD14\u2013GD15 emerge as a critical window for detecting acute perfusion impairment and evaluating interventions targeting acute injury.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70251","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T03:51:31Z","timestamp":1771818691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal 3D\u2010DCE MRI Assessment of Placental Perfusion Under Reduced Uterine Perfusion Pressure in Pregnant Rats"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1011-2669","authenticated-orcid":false,"given":"Fatimah\u00a0M.","family":"Al\u00a0Darwish","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering and Physics Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Cardiovascular Sciences  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caren\u00a0M.","family":"van Kammen","sequence":"additional","affiliation":[{"name":"Department of CDL Research University Medical Center Utrecht, Utrecht University  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fieke","family":"Terstappen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Wilhelmina Children's Hospital University Medical Center Utrecht, Utrecht University  Utrecht the Netherlands"},{"name":"Department of Neonatology, Wilhelmina Children's Hospital University Medical Center Utrecht, Utrecht University  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindy\u00a0K.","family":"Alles","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Physics Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Cardiovascular Sciences  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond\u00a0M.","family":"Schiffelers","sequence":"additional","affiliation":[{"name":"Department of CDL Research University Medical Center Utrecht, Utrecht University  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.\u00a0Titia","family":"Lely","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Wilhelmina Children's Hospital University Medical Center Utrecht, Utrecht University  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6700-5058","authenticated-orcid":false,"given":"Gustav\u00a0J.","family":"Strijkers","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Physics Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Cardiovascular Sciences  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bram\u00a0F.","family":"Coolen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Physics Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Cardiovascular Sciences  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2019.00055\/BIBTEX"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15884"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.74038"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00117.2012"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201005120\u20102"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201037310\u20102"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/AJH.2008.239"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.120881"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PLACENTA.2022.06.006"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/AJPREGU.00216.2013"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/DNA.2017.3817\/ASSET\/IMAGES\/LARGE\/FIGURE5.JPEG"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PLACENTA.2024.04.008"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00056.2024"},{"key":"e_1_2_12_15_1","unstructured":"Moby1971.P2ROUD\u2010v6.1: Preclinical PROspective Undersampling in Multiple Dimensions. 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