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The early detection and differentiation of these interconnected pathologies remain challenging. To understand the effect of cerebral and vascular A\u03b2 on regional myeloarchitecture and lipid composition, we developed a novel multimodal neuroimaging approach integrating quantitative MRI (qMRI), chemical exchange saturation transfer (CEST) MRI, and immunohistochemistry (IHC). The framework was applied to a 10\u2010month\u2010old mouse model exhibiting both cerebral and vascular amyloid pathologies. High\u2010resolution in\u00a0vivo MRI was performed using a 9.4 Tesla scanner. The results suggest region\u2010specific vulnerability to A\u03b2 pathology with significant regional increases in apparent transverse relaxation rate (R2*,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05; Hedges'\n                    <jats:italic>g<\/jats:italic>\n                    \u2009=\u20091.22) and quantitative susceptibility mapping (\n                    <jats:italic>\u03c7<\/jats:italic>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01; Hedges'\n                    <jats:italic>g<\/jats:italic>\n                    \u2009=\u20091.99) within the hippocampus of ARTE10 mice compared to wild\u2010type littermates. Multislice CEST\u2010based Z\u2010spectra were used with multipool Lorentzian fitting and quantitative T1 longitudinal relaxation maps to obtain nuclear Overhauser enhancement (NOE) weighted apparent exchange\u2010dependent relaxation (AREX) maps. NOE\n                    <jats:sub>(\u22123.5 ppm)<\/jats:sub>\n                    \u2010sensitive CEST imaging contrast showed region\u2010specific changes in the hippocampus (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01; Hedges'\n                    <jats:italic>g<\/jats:italic>\n                    \u2009=\u2009\u22121.81), corpus callosum (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01; Hedges'\n                    <jats:italic>g<\/jats:italic>\n                    \u2009=\u2009\u22122.39), and thalamus (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01; Hedges'\n                    <jats:italic>g<\/jats:italic>\n                    \u2009=\u2009\u22122.64) of ARTE10 animals relative to WT littermates. Hippocampal A\u03b2 burden, iron load, and myelin density were quantified using immunohistochemistry, suggesting strong A\u03b2 plaque presence and elevated iron load in the hippocampi of ARTE10 mice compared to WT mice. Collectively, our results demonstrate the utility of this multimodal MRI framework in identifying sensitive and specific biomarkers of amyloid\u2010driven myeloarchitectural and molecular changes. The proposed framework offers a valuable tool for enhancing early detection, understanding different pathophysiological pathways, and facilitating therapeutic monitoring and targeted intervention strategies.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70262","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:58:22Z","timestamp":1773392302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multimodal MRI Reveals Cerebral and Vascular Amyloid\u2010Driven Myeloarchitectural Disorganization in a Mouse Model of Alzheimer's Disease"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0914-6933","authenticated-orcid":false,"given":"Syed\u00a0Salman","family":"Shahid","sequence":"first","affiliation":[{"name":"Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Indiana Alzheimer's Disease Research Center Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Center for Neuroimaging, Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Dzemidzic","sequence":"additional","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin\u00a0E.","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Stark Neuroscience Research Institute Indiana University School of Medicine  Indianapolis Indiana 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