{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:29:44Z","timestamp":1773923384259,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Quantitative MRI (\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    \u2013\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    ) has been shown to be useful for early diagnosis of osteoarthritis (OA) in the knee at 1.5 and 3\u2009T. However, limited research has been performed at 0.55\u2009T. In this study, we aim to develop and evaluate the feasibility of a 3D joint\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    \u2013\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    mapping estimation and synthetic contrasts radial sequence for quantitative and anatomical water\u2010fat imaging of the knee at 0.55\u2009T. The proposed sequence consists of a free\u2010running, 3D\u2010golden angle radial trajectory preceded with inversion recovery and \u2010preparation pulses. Reconstruction of images is performed with parallel imaging and high\u2010dimensional low\u2010rank patch\u2010based regularization. A water\u2013fat separation technique is employed to obtain water and fat images, and\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    \u2013\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    maps can be obtained for water and the echo images via Bloch\u2010equation dictionary matching. The sequence was validated on a standardized phantom and in 16 healthy subjects. Phantom results are in good agreement with SE references, with biases of \u2009ms for  and  ms for . In\u00a0vivo, the average mean in the articular cartilage was  ms and  ms, compared to  ms,  ms for the reference sequences. Synthetic contrast images produced with the sequence are comparable to the references in terms of contrast to noise ratio (CNR) and relative contrast metrics. The feasibility of 3D joint\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    \u2013\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    mapping of the knee at 0.55\u2009T in a single scan of ~3\u2009min was demonstrated, showing promising results for efficient knee imaging. Studies in a larger cohort of patients with osteoarthritis at 0.55\u2009T are now warranted.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70265","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:57:49Z","timestamp":1773755869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["3D Radial Knee Imaging at 0.55\u2009T: Simultaneous\n                    <i>T<\/i>\n                    <sub>1<\/sub>\n                    \u2013\n                    <i>T<\/i>\n                    <sub>2<\/sub>\n                    Mapping and Synthetic Contrast Generation in Under 4\u2009min"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6377-4059","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Garrido","sequence":"first","affiliation":[{"name":"Institute for Biological and Medical Engineering Pontificia Universidad Cat\u00f3lica de Chile  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