{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:29:39Z","timestamp":1773923379678,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371932"],"award-info":[{"award-number":["82371932"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Clinically significant prostate cancer (csPCa) and benign prostate tissue are composed of distinct cell populations. Selective size imaging using filters via diffusion times (SSIFT) MRI, a novel technique generating cell size\u2013weighted maps sensitive to specific cell sizes (e.g., cancer cells), has an unclear clinical value in prostate cancer. This study aimed to evaluate whether SSIFT MRI can serve as a novel imaging biomarker for prostate cancer, specifically for discriminating csPCa from clinically insignificant disease (CIS). A total of 152 men (89 with csPCa and 63 with CIS) suspected of csPCa were prospectively enrolled, with 229 lesions (93 with csPCa and 136 with CIS) delineated. SSIFT MRI data were acquired using pulsed and oscillating gradient diffusion sequences to generate incremental AUC (iAUC). We evaluated the performance of iAUC, the apparent diffusion coefficient (ADC), and prostate\u2010specific antigen density (PSAD) in discriminating csPCa from CIS and assessing Gleason grade group (GGG). Additionally, correlations between iAUC and pathologic parameters (nuclei fraction, diameter, and cellularity) were analyzed in patients with whole histopathologic slides. Higher GGG was associated with increased iAUC values (GGGs 1\u20135: 3.34%\u2009\u00b1\u20091.28%, 5.31%\u2009\u00b1\u20092.33%, 6.18%\u2009\u00b1\u20092.71%, 6.36%\u2009\u00b1\u20092.23%, and 6.23%\u2009\u00b1\u20091.15%, respectively). For distinguishing csPCa from CIS, iAUC exhibited the highest diagnostic performance, with AUCs of 0.91 (peripheral zone), 0.86 (transitional zone), and 0.89 (whole prostate). In per\u2010patient analysis, the combined model incorporating iAUC, ADC_50ms, and PSAD achieved the highest diagnostic accuracy (86%, 131\/152) and AUC (0.93; 95% CI: 0.88\u20130.97). Histopathological analysis revealed a mean prostate cancer nuclei diameter of 10.98\u2009\u00b1\u20091.81\u2009\u03bcm, within the SSIFT filter range (10\u201320\u2009\u03bcm). These findings suggest that SSIFT MRI shows promise as a novel imaging biomarker for prostate cancer, enabling noninvasive identification of csPCa and optimizing clinical decision\u2010making.<\/jats:p>","DOI":"10.1002\/nbm.70267","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:53:41Z","timestamp":1773406421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selective Cell Size MRI for the Diagnosis and Grading of Clinically Significant Prostate Cancer: A Feasibility Study"],"prefix":"10.1002","volume":"39","author":[{"given":"Hao","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Radiology Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing P. R. China"},{"name":"Graduate School of Peking Union Medical College  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomedical Engineering of the Ministry of Education, Department of Biomedical Engineering College of Biomedical Engineering and Instrument Science, Zhejiang University  Hangzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4770-4449","authenticated-orcid":false,"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxia","family":"Zhu","sequence":"additional","affiliation":[{"name":"MR Research Collaboration Siemens Healthineers  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing P. R. China"},{"name":"Graduate School of Peking Union Medical College  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9303-5821","authenticated-orcid":false,"given":"Dan","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomedical Engineering of the Ministry of Education, Department of Biomedical Engineering College of Biomedical Engineering and Instrument Science, Zhejiang University  Hangzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3935-7771","authenticated-orcid":false,"given":"Chunmei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing P. R. China"},{"name":"Graduate School of Peking Union Medical College  Beijing P. R. 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