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Cardiopulmonary bypass (CPB) is a standard procedure, but infants undergoing CPB show an increased risk of postoperative white matter injury. These injuries are associated with adverse neurodevelopmental outcomes, yet the underlying mechanisms remain poorly understood. MR imaging offers unique opportunities to study cerebral perfusion and metabolism in\u00a0vivo but has not previously been feasible during CPB with a heart\u2010lung machine (HLM) in close proximity to the patient and the MR scanner, respectively, because conventional HLMs interfere with scanner operation. To address this limitation, we developed an MR\u2010conditional HLM and evaluated it in an in\u00a0vivo piglet model, which closely mimics the neonatal brain and circulation. Unlike conventional systems, our MR\u2010conditional roller pump can be positioned directly inside the scanner bore without compromising imaging quality or pump performance. Four trials were conducted, in which piglets were cannulated and maintained on CPB inside the MR scanner. During CPB, cooling, rewarming, and unilateral carotid clamping were performed while repeatedly acquiring MR data on flow, diffusion, perfusion, and metabolism. Crucial brain structures\u2014including the basal ganglia, hippocampus, and internal capsule\u2014were consistently visualized without artifacts, and no disturbances occurred in pump operation or monitoring signals. The MR scans revealed flow\u2010related changes and a progressive increase in lactate, suggesting the onset of metabolic stress under hypoperfusion. These results demonstrate the technical feasibility of performing CPB within the MR scanner using an MR\u2010conditional HLM. Although not sufficient to identify specific mechanisms of brain injury, this platform provides a unique foundation for mechanistic studies in relevant large\u2010animal models. In the future, such an approach could help identify early markers of cerebral vulnerability, improve the safety of pediatric cardiac surgery, and inform the development of neuroprotective strategies for CPB and extracorporeal membrane oxygenation patients.<\/jats:p>","DOI":"10.1002\/nbm.70284","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T03:51:01Z","timestamp":1775447461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cerebral Hemodynamic Changes During Cardiac Surgery: A Feasibility MR Study in Piglets"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0188-6726","authenticated-orcid":false,"given":"Dominik\u00a0T.","family":"Schulte","sequence":"first","affiliation":[{"name":"Institute for Dynamic Systems and Control ETH Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"O'Gorman\u00a0Tuura","sequence":"additional","affiliation":[{"name":"Centre for MR Research Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3696-6993","authenticated-orcid":false,"given":"Henning","family":"Richter","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Research Unit, Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Centre for Cardiac Surgery, University Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8996-1961","authenticated-orcid":false,"given":"Francesca","family":"del Chicca","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Research Unit, Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Aigner","sequence":"additional","affiliation":[{"name":"Centre for Cardiac Surgery, University Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Loeschmann","sequence":"additional","affiliation":[{"name":"Centre for Cardiac Surgery, University Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Lentini","sequence":"additional","affiliation":[{"name":"Anesthesiology Animal Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0212-6021","authenticated-orcid":false,"given":"Manuela","family":"Wieser","sequence":"additional","affiliation":[{"name":"Anesthesiology Animal Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frauke","family":"Seehusen","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rima","family":"Bektas","sequence":"additional","affiliation":[{"name":"Anesthesiology Animal Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Zeilinger","sequence":"additional","affiliation":[{"name":"Institute for Dynamic Systems and Control ETH Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin\u00a0O.","family":"Schmiady","sequence":"additional","affiliation":[{"name":"Centre for Cardiac Surgery, University Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6411-8871","authenticated-orcid":false,"given":"Marianne","family":"Schmid\u00a0Daners","sequence":"additional","affiliation":[{"name":"Institute for Dynamic Systems and Control ETH Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,5]]},"reference":[{"issue":"6","key":"e_1_2_12_2_1","article-title":"Single Ventricle\u2010A Comprehensive Review","volume":"8","author":"Rao P. 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