{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T06:56:57Z","timestamp":1776322617595,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cardiac adaptation to chronic pressure overload is traditionally viewed as a uniform concentric hypertrophy; however, growing evidence suggests that the myocardium responds in a spatially heterogeneous manner. This study aimed to systematically map regional and temporal adaptation patterns of the left ventricle (LV) under experimental pressure overload using high\u2010resolution multiparametric cardiac MRI, with the hypothesis that distinct regional adaptation phenotypes contribute to both local functional differences and global ventricular dysfunction. Thirty\u2010seven male 129\/SvEv mice underwent transverse aortic constriction (TAC) surgery and were followed longitudinally over 7\u2009weeks. Cine imaging, T1\u2010 and T2\u2010mapping were performed at baseline, 3\u2009days, 4\u2009weeks and 7\u2009weeks using a 9.4\u2009T small\u2010animal scanner. A 200\u2010sector LV segmentation enabled quantitative regional analysis of wall thickness, fractional shortening (FS) and relaxation times. Global and regional imaging parameters were correlated with histological and biochemical indices at study termination, and statistical analyses were performed using the Mann\u2013Whitney test and correlation modelling, with\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05 considered significant. All TAC animals developed global LV hypertrophy and an early increase in LV mass (+62%\u2009\u00b1\u200915% at Week 7,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Unexpectedly, in 18 animals (49%), a discrete basolateral LV segment failed to hypertrophy (spared hypertrophy, SH) despite uniform pressure elevation. This region exhibited markedly reduced regional FS (10.2%\u2009\u00b1\u20093.1% vs. 24.9%\u2009\u00b1\u20092.2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01) and was associated with lower global ejection fraction (32.5%\u2009\u00b1\u20091.8% vs. 49.8%\u2009\u00b1\u20094.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and LV dilatation. Parametric MRI revealed distinct tissue signatures: T1 increased in hypertrophied sectors (+22.6%\u2009\u00b1\u20091.1%), whereas it decreased in SH sectors (\u22125.1%\u2009\u00b1\u20091.7%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) over the 7\u2010week observation period. Sector\u2010wise correlations linked T1 shortening with reduced FS (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.58,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002), suggesting maladaptive regional remodeling. In conclusion, pressure overload elicits diverse regional adaptation, and failure to hypertrophy identifies myocardial territories prone to early dysfunction and global decline. Recognizing hypertrophy as an essential adaptive mechanism shifts the paradigm of pressure\u2010overload remodeling. Multiparametric MRI provides a translational platform for detecting regional vulnerability and guiding early intervention.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70288","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:41:53Z","timestamp":1775803313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heterogeneous Myocardial Adaptation to Pressure Overload Reveals a Spared, Vulnerable Segment Identified by Multiparametric Cardiac MRI"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6915-5906","authenticated-orcid":false,"given":"Vitali","family":"Koch","sequence":"first","affiliation":[{"name":"Goethe University Frankfurt, University Hospital Department of Radiology  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas\u00a0T.","family":"Ochs","sequence":"additional","affiliation":[{"name":"Goethe University Frankfurt, University Hospital Department of Cardiology and Angiology  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Martin","sequence":"additional","affiliation":[{"name":"Goethe University Frankfurt, University Hospital Department of Radiology  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Vogl","sequence":"additional","affiliation":[{"name":"Goethe University Frankfurt, University Hospital Department of Radiology  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco\u00a0M.","family":"Ochs","sequence":"additional","affiliation":[{"name":"Goethe University Frankfurt, University Hospital Department of Cardiology and Angiology  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David\u00a0M.","family":"Leistner","sequence":"additional","affiliation":[{"name":"Goethe University Frankfurt, University Hospital Department of Cardiology and Angiology  Frankfurt Germany"},{"name":"German Center of Cardiovascular Research (DZHK) Partner Site Rhine\/Main  Frankfurt Germany"},{"name":"Cardiopulmonary Institute (CPI)  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3100-2167","authenticated-orcid":false,"given":"Sebastian\u00a0M.","family":"Haberkorn","sequence":"additional","affiliation":[{"name":"Goethe University Frankfurt, University Hospital Department of Cardiology and Angiology  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00092"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.03.036"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi290"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3014693"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvae045"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00887-x"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.659666"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.02.010"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27848"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1072828"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21548-x"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-005-0542-7"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-014-0430-0"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1566"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20399"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-020-00655-7"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-012-0141-2"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.007451"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00374.2015"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00806-6"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-019-01271-w"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0102.101365"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.003285"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.976738"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa587"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00384.2002"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62201-2"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.041694"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.03.240"}],"container-title":["NMR 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