{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T05:04:24Z","timestamp":1779771864516,"version":"3.53.1"},"reference-count":71,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009068","name":"University of Bern","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["2003B_184943"],"award-info":[{"award-number":["2003B_184943"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003986","name":"Jacobs Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003986","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Early adolescence is a critical period of brain development. This study examined regional neurometabolite ratios, their longitudinal stability, and their heritability during early adolescence. Forty\u2010four adolescent twins (mean age: 13.25\u2009years; SD\u2009=\u20091.01\u2009years; 18 females; 25 monozygotic twins) underwent magnetic resonance spectroscopy (MRS) of the prefrontal cortex (GABA\u2010edited MEGA\u2010PRESS) and thalamus (short\u2010echo\u2010time PRESS) at baseline and 6 months later (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200932; mean age: 13.72\u2009years; SD\u2009=\u20090.97; 14 females; 19 monozygotic twins). We observed stable neurometabolite ratios in both regions across time. Moderate genetic contributions were estimated for Glx (glutamate and glutamine)\/(Cr\u2009+\u2009PCr) in the prefrontal cortex as well as for glutamate\/(Cr\u2009+\u2009PCr) and total choline\u2010containing compounds (PCho + GPC)\/(Cr\u2009+\u2009PCr) in the thalamus. These preliminary findings highlight region\u2010specific and genetically influenced neurometabolic markers in early adolescence.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70292","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T02:35:01Z","timestamp":1776652501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurometabolic Stability and Heritability in the Adolescent Brain: A Preliminary Longitudinal Twin MRS Study"],"prefix":"10.1002","volume":"39","author":[{"given":"Christoph","family":"Hamann","sequence":"first","affiliation":[{"name":"Division of Child and Adolescent Psychiatry and Psychosomatic Medicine, Department of Pediatrics Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andjela","family":"Markovic","sequence":"additional","affiliation":[{"name":"Translational Research Center, University Hospital of Psychiatry and Psychotherapy University of Bern  Bern Switzerland"},{"name":"Department of Psychology University of Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Caccia","sequence":"additional","affiliation":[{"name":"Division of Child and Adolescent Psychiatry and Psychosomatic Medicine, Department of Pediatrics Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Badek","sequence":"additional","affiliation":[{"name":"Division of Child and Adolescent Psychiatry and Psychosomatic Medicine, Department of Pediatrics Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salome","family":"Wild","sequence":"additional","affiliation":[{"name":"Translational Research Center, University Hospital of Psychiatry and Psychotherapy University of Bern  Bern Switzerland"},{"name":"University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of Bern  Bern Switzerland"},{"name":"Graduate School for Health Sciences University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Adorjan","sequence":"additional","affiliation":[{"name":"Translational Research Center, University Hospital of Psychiatry and Psychotherapy University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kaess","sequence":"additional","affiliation":[{"name":"University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Tuura","sequence":"additional","affiliation":[{"name":"MR\u2010Research Centre University Children's Hospital Zurich  Zurich Switzerland"},{"name":"University of Zurich  Zurich Switzerland"},{"name":"Children's Research Centre University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4014-428X","authenticated-orcid":false,"given":"Leila","family":"Tarokh","sequence":"additional","affiliation":[{"name":"Translational Research Center, University Hospital of Psychiatry and Psychotherapy University of Bern  Bern Switzerland"},{"name":"University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2513"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467\u20108721.00072"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1506488112"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402680101"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.5302\u201010.2011"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858411422114"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12721"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/ijamh\u20102015\u20105005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.12155.1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.664535"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11689\u2010025\u201009614\u20108"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10697"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101838"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010023\u201002514\u20102"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.104"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09070994"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.644315"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.90"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061731"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.10.017"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119740"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10286"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9060522"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.65.092101.142131"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1772"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.120194"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.10.017"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.167"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010021\u201001152\u2010w"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.03.001"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010022\u201004126\u2010w"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.06.027"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2017.04.001"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3285"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127\u2010016\u20101178\u20107"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201025590\u20107"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0945\u201018.2018"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.16568"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010022\u201002106\u20106"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhaa151"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910300604"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099\u20101492(200005)13:3<129::aid\u2010nbm619>3.0.co;2\u2010v"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11336\u2010010\u20109200\u20106"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301\u20100511(02)00051\u20100"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/3.2.119"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2022.102370"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.04.040"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24225"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.101"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.03.031"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2012.11.003"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24123"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1159\/000478861"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0301\u20100082(00)00059\u20109"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00037"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22575"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20494"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm211"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010018\u20100236\u20100"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.09.016"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2006.06.001"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.12.097"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2322"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.1880"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4910"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.678709"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.01.001"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117509"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/medsci6020046"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1037\/bul0000053"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.70292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nbm.70292","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.70292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T04:30:40Z","timestamp":1779769840000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.70292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,19]]},"references-count":71,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/nbm.70292"],"URL":"https:\/\/doi.org\/10.1002\/nbm.70292","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,19]]},"assertion":[{"value":"2025-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70292"}}