{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:30:41Z","timestamp":1793136641837,"version":"4.5.0"},"reference-count":66,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01\u2010HL153430"],"award-info":[{"award-number":["R01\u2010HL153430"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Measuring cyclic changes in intramyocardial blood volume (iMBV) from systole to diastole has been used as an imaging marker for assessing coronary microcirculation and detecting coronary artery disease (CAD) without the need for vasodilator stress. However, an MRI\u2010based method for detecting cyclic iMBV dynamics does not exist. The aim of this study is to demonstrate the feasibility of using ferumoxytol\u2010enhanced (FE) MRI to detect systolic\u2010to\u2010diastolic iMBV dynamics on clinical scanners enabled by a new myocardial \u201cT1 tracking\u201d technique. To this end, a continuous steady\u2010state sequence was developed, combining slice\/slab\u2010selective excitation, to generate high\u2010resolution T1\u2010weighted images such that the myocardial signal dynamically tracks the fractional volume of blood while minimizing the influence of confounding factors such as in\u2010flow effects, through\u2010plane motion, and spin history. In addition to phantom studies, FE studies in swine (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910) were conducted to generate systolic\/diastolic T1 maps from the T1\u2010tracking data. For comparison, MOLLI T1 maps were acquired. For both the T1\u2010tracking method and MOLLI, T1 values before\/after ferumoxytol were used to calculate iMBV at end\u2010systole (ES) and end\u2010diastole (ED). The T1\u2010tracking method showed a significant iMBV difference between ES and ED (ES: 6.2\u2009\u00b1\u20091.8%, ED: 7.7\u2009\u00b1\u20092.0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u200910\n                    <jats:sup>\u22123<\/jats:sup>\n                    ) as opposed to MOLLI (ES: 8.1\u2009\u00b1\u20092.9%, ED: 8.6\u2009\u00b1\u20093.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.4), and detected lower iMBV at ES vs. ED in all 10 studies, consistent with physiology, while MOLLI showed contradictory ES\u2010to\u2010ED change in 3 out of 10 studies. The proposed method showed a mean iMBV decrease of 19.1% from ED to ES, consistent with the nuclear imaging literature. In conclusion, the results show that the newly developed FE myocardial T1\u2010tracking technique captures cyclic changes in iMBV, i.e., consistently reveals the expected drop in iMBV from diastole to systole, offering the potential to detect CAD without the need for pharmacological stress.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70308","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:10:53Z","timestamp":1779167453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ferumoxytol\u2010Enhanced Myocardial T1 Tracking Using a Hybrid 2D\/3D Steady\u2010State MRI Sequence Captures Cyclic Intramyocardial Blood Volume Dynamics"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2642-1835","authenticated-orcid":false,"given":"Hazar Benan","family":"Unal","sequence":"first","affiliation":[{"name":"Laboratory for Translational Imaging of Microcirculation Purdue University  Indianapolis Indiana USA"},{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette Indiana USA"},{"name":"Division of Cardiovascular Medicine Indiana Univ. School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahriar","family":"Zeynali","sequence":"additional","affiliation":[{"name":"Laboratory for Translational Imaging of Microcirculation Purdue University  Indianapolis Indiana USA"},{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette Indiana USA"},{"name":"Division of Cardiovascular Medicine Indiana Univ. School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Ahmed","sequence":"additional","affiliation":[{"name":"MR R&amp;D Collaborations, Siemens Medical Solutions USA  Indianapolis Indiana USA"},{"name":"Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Anttila","sequence":"additional","affiliation":[{"name":"MED Institute  West Lafayette Indiana USA"},{"name":"Bindley Bioscience Center Purdue University  West Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Mastouri","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Indiana Univ. School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2110-607X","authenticated-orcid":false,"given":"Rolf P.","family":"Kreutz","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Indiana Univ. School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Dharmakumar","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette Indiana USA"},{"name":"Division of Cardiovascular Medicine Indiana Univ. School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Gross","sequence":"additional","affiliation":[{"name":"MED Institute  West Lafayette Indiana USA"},{"name":"Bindley Bioscience Center Purdue University  West Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8945-8178","authenticated-orcid":false,"given":"Behzad","family":"Sharif","sequence":"additional","affiliation":[{"name":"Laboratory for Translational Imaging of Microcirculation Purdue University  Indianapolis Indiana USA"},{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette Indiana USA"},{"name":"Division of Cardiovascular Medicine Indiana Univ. School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Elmore Family School of Electrical &amp; Computer Engineering Purdue University  West Lafayette Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.272.1.H567"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.97.5.473"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006427"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4518"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27494"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29530"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2024.132479"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10976640701545206"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554\u2010019\u201001554\u20104"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00588169"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1973.224.4.918"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2005"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517\u2010008\u20100335\u2010x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.68.1.217"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350\u2010017\u20100970\u20104"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.089631"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1992.263.3.H963"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0502.102964"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0202.101986"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.278.2.H383"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.58.4.476"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.74.6.1157"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0008\u20106363(02)00736\u20108"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.96.3.1004"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.06.066"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.05.010"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26975"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.14534"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20110"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10175"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23318"},{"key":"e_1_2_12_33_1","unstructured":"B.Sharif R.Dharmakumar D. 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