{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T05:04:30Z","timestamp":1779771870177,"version":"3.53.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002752","name":"Bodossaki Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002752","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>T2* Magnetic Resonance Imaging (MRI) is an established method for the assessment of iron overload in multiple organs. Quantification of iron in the soft tissues of the fingers with T2* MRI could be of clinical value in conditions characterized by microvasculopathy. Herein, we examined the feasibility and repeatability of quantitative T2* MRI for the presence of iron in the soft tissues of fingers. In this prospective cohort study, 10 healthy individuals and three patients with digital microvasculopathy were subjected to hand MRI. Gradient echo (GRE) images with progressively increasing echo times (TE's) were acquired in a 1.5\u2009T MRI system. After visual inspection of dual\u2010colored maps of the hands, multiple regions of interest (ROIs) were placed in the soft tissues at areas that indicated increased susceptibility. Three ROIs per finger with the lowest T2* values (ms) were recorded. Mean T2* values for healthy individuals ranged from 12.5 to 16.0\u2009ms (mean\u2009\u00b1\u2009standard deviation [SD]: 14.0\u2009\u00b1\u20092.6\u2009ms) except for a single ROI measurement of 8.8\u2009ms in one individual. In contrast, multiple ROIs with T2* values below 8.8\u2009ms were detected in the soft tissues of the three patients with digital microvasculopathy. The range of values for the three patients were (mean\u2009\u00b1\u2009SD [range]: 7.4\u2009\u00b1\u20090.9 [5.2\u20138.8] ms, 7.9\u2009\u00b1\u20091.0 [5.9\u201310.3] ms, and 7.9\u2009\u00b1\u20091.7 [5.7\u201314.3] ms, respectively), suggestive of iron excess. Furthermore, 4\/10 healthy individuals repeated the examination 1\u2009year after the first MRI study. No areas with T2* below 8.8\u2009ms were detected in the second study. In conclusion, T2* GRE is a feasible and reproducible technique for the quantification of iron in the soft tissues of the fingers.<\/jats:p>","DOI":"10.1002\/nbm.70314","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:53:56Z","timestamp":1779339236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative T2* Magnetic Resonance Imaging for Iron Detection in Soft Tissue of the Fingers"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9022-7320","authenticated-orcid":false,"given":"Artemis","family":"Galani","sequence":"first","affiliation":[{"name":"First Department of Radiology, School of Medicine National and Kapodistrian University of Athens, Areteion Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7878-8078","authenticated-orcid":false,"given":"Nikolaos 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