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Biopsies sampled from the index tumor and a presumed tumor\u2010free area of eight prostatectomy specimens underwent diffusion\u2010weighted imaging using conventional pulsed gradient spin echoes (PGSE) and stimulated echo acquisition mode (STEAM) with different gradient separation times between 10 and 400\u2009ms at nominal\n                    <jats:italic>b<\/jats:italic>\n                    values ranging from 0 up to 5000\u2009s\/mm\n                    <jats:sup>2<\/jats:sup>\n                    . The apparent diffusion coefficient (ADC) was determined over the\n                    <jats:italic>b<\/jats:italic>\n                    \u2010value range 0\u20131000\u2009s\/mm\n                    <jats:sup>2<\/jats:sup>\n                    . Kurtosis and biexponential models were fitted to measured signals at effective\n                    <jats:italic>b<\/jats:italic>\n                    values within the range 0\u20132000 and 0\u20135000\u2009s\/mm\n                    <jats:sup>2<\/jats:sup>\n                    , respectively. Moreover, monoexponential models were fitted over the same\n                    <jats:italic>b<\/jats:italic>\n                    \u2010value ranges. After imaging, all biopsies underwent histopathological evaluation. For all diffusion gradient separation times evaluated, the ADC of histopathologically confirmed tumor and normal tissue was not significantly different (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.140 at 10\u2009ms gradient separation time). Irrespective of the investigated tissue type, for an increasing gradient separation time up to 150\u2009ms ADC decreased. For longer times up to 400\u2009ms no further change was evident. For short diffusion gradient separation times, the Akaike information criterion (AIC) favored the biexponential model in almost all voxels, but for longer diffusion gradient separation times, in a majority of voxels the AIC favored the monoexponential model over either the kurtosis or biexponential model. Imaging of fresh prostate biopsies is feasible. At short diffusion times, in agreement with the presence of at least two distinct compartments, the signal decay is well described by a biexponential model. At long diffusion times, the ADC is lower, and a monoexponential model tends to be more appropriate, indicating the presence of exchange between compartments.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70316","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:12:42Z","timestamp":1779433962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetic Resonance Imaging at 14 Tesla of Prostate Biopsies Obtained after Prostatectomy"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8706-4036","authenticated-orcid":false,"given":"Fredrik","family":"Langkilde","sequence":"first","affiliation":[{"name":"Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Radiology Sahlgrenska University Hospital  Gothenburg 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