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This study aimed to quantify alterations in myocardial motion velocity in the functional ventricle of Fontan patients using TPM and to investigate the relationship between myocardial motion and cardiac function. We prospectively enrolled 28 Fontan patients and 42 age\u2010 and sex\u2010matched normal controls. Myocardial motion velocities were assessed using TPM in the longitudinal (V\n                    <jats:sub>z<\/jats:sub>\n                    ), radial (V\n                    <jats:sub>r<\/jats:sub>\n                    ), and circumferential (\n                    <jats:italic>V<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>phi<\/jats:italic>\n                    <\/jats:sub>\n                    ) directions. We evaluated the peak velocities, time\u2010to\u2010peak (TTP\n                    <jats:sub>z<\/jats:sub>\n                    , TTP\n                    <jats:sub>r<\/jats:sub>\n                    ), and dyssynchrony index (DI\n                    <jats:sub>z<\/jats:sub>\n                    , DI\n                    <jats:sub>r<\/jats:sub>\n                    ). Circumferential motion abnormalities were assessed using peak\u2010to\u2010peak (PTP) values,\n                    <jats:italic>V<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>phi<\/jats:italic>\n                    <\/jats:sub>\n                    inconsistency, and twist. Compared to controls, Fontan patients demonstrated significantly reduced peak V\n                    <jats:sub>z<\/jats:sub>\n                    and V\n                    <jats:sub>r<\/jats:sub>\n                    during both systole and diastole (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), as well as prolonged systolic TTP\n                    <jats:sub>z<\/jats:sub>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) and TTP\n                    <jats:sub>r<\/jats:sub>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Diastolic DI\n                    <jats:sub>z<\/jats:sub>\n                    was increased (p\u2009&lt;\u20090.001), whereas systolic DI\n                    <jats:sub>r<\/jats:sub>\n                    was decreased (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). In multivariable regression analysis, ejection fraction of Fontan patients positively correlated with peak systolic V\n                    <jats:sub>r<\/jats:sub>\n                    and negatively correlated with mid\n                    <jats:italic>V<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>phi<\/jats:italic>\n                    <\/jats:sub>\n                    PTP (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.639). The cardiac output was positively associated with peak systolic V\n                    <jats:sub>r<\/jats:sub>\n                    and diastolic DI\n                    <jats:sub>z<\/jats:sub>\n                    (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.578). TPM may provide quantitative MR biomarkers for regional myocardial motion abnormalities, including impaired myocardial motion velocities, delayed contraction timing, and altered motion synchronization, in Fontan patients. These findings suggest global ventricular dysfunction and may provide insight into the mechanisms underlying reduced ejection fraction and cardiac output in the functional ventricle physiology in Fontan patients.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70333","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:31:29Z","timestamp":1782282689000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Assessment of Myocardial Velocity and Dyssynchrony in Fontan Circulation Using MR Tissue Phase Mapping"],"prefix":"10.1002","volume":"39","author":[{"given":"Xue\u2010Zhe","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University  Hsinchu 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