{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:07:32Z","timestamp":1784185652246,"version":"3.55.0"},"reference-count":63,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR070101"],"award-info":[{"award-number":["R01AR070101"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR085068"],"award-info":[{"award-number":["R01AR085068"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Duchenne muscular dystrophy (DMD) is an X\u2010linked recessive condition that is characterized by muscle deterioration, loss of functional abilities, and shortened lifespan. There is growing evidence of skeletal muscle mitochondrial impairments in DMD, and\n                    <jats:sup>31<\/jats:sup>\n                    phosphorous magnetic resonance spectroscopy (\n                    <jats:sup>31<\/jats:sup>\n                    P\u2010MRS) provides a noninvasive marker of functional oxidative capacity of muscle. Therefore, the purpose of this study was to examine\n                    <jats:sup>31<\/jats:sup>\n                    P\u2010MRS indices of energetic status and oxidative capacity in DMD and correlate with clinical functional measures. In this study, we evaluated ambulatory participants with DMD (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200921, 8.7\u2009\u00b1\u20091.9\u2009years) and unaffected age\u2010matched controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920, 9.0\u2009\u00b1\u20092.8\u2009years) using a 3T MR system.\n                    <jats:sup>31<\/jats:sup>\n                    P\u2010MRS was used to measure relative changes in high\u2010energy phosphates and muscle pH of the anterior compartment of the lower leg during and following isometric dorsiflexion muscle contractions (120\u2009s rest, 60\u2009s of contractions at 0.5\u2009Hz, and 420\u2009s recovery). Data were analyzed with jMRUI (v7.0), and a mono\u2010exponential model was used to estimate the time constant (tau) of PCr recovery (PCr\u03c4). We observed that relative concentrations of inorganic phosphate to phosphocreatine (Pi\/PCr) and phosphodiesters to ATP (PDE\/ATP) were elevated (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) in DMD compared to controls, and the PCr\u03c4 recovery was slower (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) in DMD than controls. PCr\u03c4 recovery was correlated with the distance covered in the 6\u2010min walk test (6MWT) (\n                    <jats:italic>\u03c1<\/jats:italic>\n                    \u2009=\u2009\u22120.61,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and other timed functional measures (\n                    <jats:italic>\u03c1<\/jats:italic>\n                    \u2009=\u20090.54\u20130.67,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The findings from this study demonstrated that energetic status is altered and PCr recovery time is impaired in ambulatory boys with DMD indicating reduced oxidative capacity compared to unaffected controls. Overall, these findings support the use of\n                    <jats:sup>31<\/jats:sup>\n                    P\u2010MRS as a valuable noninvasive tool to evaluate skeletal muscle energetics and mitochondrial function in individuals with DMD.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70336","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T06:31:29Z","timestamp":1782109889000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Basal Energetics and Phosphocreatine Recovery Kinetics in Ambulatory Boys With Duchenne Muscular Dystrophy"],"prefix":"10.1002","volume":"39","author":[{"given":"Pratiksha P.","family":"Awale","sequence":"first","affiliation":[{"name":"Department of Physical Therapy University of Florida  Gainesville Florida 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