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M\u00f8ller og Hustru Chastine Mc-Kinney M\u00f8llers Fond til almene Formaal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF18SA0034956"],"award-info":[{"award-number":["NNF18SA0034956"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Splanchnic vessel blood flow assessment can describe physiology or pathophysiology and also has clinical relevance for patients with altered abdominal blood flow, vascular neuropathy, or atherosclerotic conditions. Reliable and practicable methods for this assessment are needed. We assessed the reproducibility of non\u2010invasive phase\u2010contrast MRI (PC\u2010MRI) for measuring splanchnic blood flow and its feasibility for detecting postprandial blood flow changes. We included measurements from two groups of healthy individuals (Group A:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910; C:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910) and a group of patients with type 2 diabetes (B:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910) from randomized, single\u2010blind, placebo\u2010controlled studies, and assessed blood flow with 2D PC sequences (3 Tesla Siemens Biograph MRI and 3 Tesla Philips Achieva). Blood flow was measured in the arteria mesenterica superior, truncus coeliacus, arteria hepatica (Group A only), and vena portae hepatis over multiple days, with repeated scans each day to assess variability and reproducibility. To confirm detection of postprandial changes, nine repeated measurements were acquired during ingestion of 75\u2010g oral glucose tolerance test compared to water ingestion. Reproducibility was assessed by coefficient of variation (CoV) and limits of agreement with the mean (LoAM) using an extended Bland\u2013Altman analysis. Blood flow in arteria mesenterica superior, truncus coeliacus, and vena portae hepatis demonstrated low intrasubject within session CoV (7%\u201322%) and intrasubject between session CoV (16%\u201326%). Blood flow in arteria hepatica had poorer CoV for both within sessions (12%) and between sessions (32%). Glucose ingestion induced a blood flow peak increase of 88%\u2009\u00b1\u200952% in arteria mesenterica superior and 68%\u2009\u00b1\u200936% in vena portae hepatis, both robustly detected, while no change was observed in the arteria hepatica or truncus coeliacus. In conclusion, PC\u2010MRI is a reproducible and feasible technique for measuring blood flow in arteria mesenterica superior, truncus coeliacus, and vena portae hepatis with the ability to detect postprandial changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: NCT05391581, NCT06426823, NCT06774807<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nbm.70348","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:04:43Z","timestamp":1782777883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reproducibility of Splanchnic Blood Flow Measured Using Phase\u2010Contrast MRI"],"prefix":"10.1002","volume":"39","author":[{"given":"L\u00e6rke S.","family":"Gasbjerg","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital, Rigshospitalet  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederikke H.","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus S.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludvig S.","family":"Langberg","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-038X","authenticated-orcid":false,"given":"Sophie W.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"Alstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital, Rigshospitalet  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanne S. W.","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital, Rigshospitalet  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2214-0496","authenticated-orcid":false,"given":"Ulrik B.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital, Rigshospitalet  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik B. W.","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital, Rigshospitalet  Glostrup Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Asmar","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine Bispebjerg and Frederiksberg Hospital, University Hospital of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9721-4712","authenticated-orcid":false,"given":"Bryan","family":"Haddock","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital, Rigshospitalet  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B.","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital, Rigshospitalet  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-382026-6.00013-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i9.1393"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20222008"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2000.5862"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afae022"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.10.1268"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286\u2010018\u20100519\u2010x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286\u2010011\u20100119\u20105"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.06.023"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00057.2024"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2025.102118"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1570603"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/db25\u20100149"},{"key":"e_1_2_11_15_1","volume-title":"GIP Contributes to Postprandial Regulation of Splanchnic Blood Supply in Humans With Type 2 Diabetes: A Randomised, Single\u2010Blinded, Placebo\u2010Controlled, Crossover Study","author":"Rasmussen R. 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