{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T06:24:44Z","timestamp":1787207084481,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014434","name":"Narodowa Agencja Wymiany Akademickiej","doi-asserted-by":"publisher","award":["25\/NAWA\u2010PROM\u2010UR\/2019"],"award-info":[{"award-number":["25\/NAWA\u2010PROM\u2010UR\/2019"]}],"id":[{"id":"10.13039\/501100014434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Parotid tumors exhibit diverse biomechanical and microstructural characteristics that remain challenging to characterize noninvasively. This study aimed to investigate these properties using ex\u00a0vivo tabletop magnetic resonance elastography (MRE) combined with multiparametric MRI, including relaxometry, diffusion\u2010weighted imaging, and fat quantification. Twelve patients (six males, six females; mean age 60.3\u2009\u00b1\u200911.2\u2009years) undergoing parotid tumor resection were included. Resected specimens were assessed histopathologically according to the WHO Classification of Head and Neck Tumors (5th edition, 2022) and imaged within 36\u2009h postresection using two\u2010dimensional Bessel\u2010MRE alongside T1 and T2 relaxometry, diffusion imaging, and fat fraction mapping. MRE\u2010derived parameters included shear wave speed (SWS), penetration rate (PR), elasticity (\n                    <jats:italic>\u03bc<\/jats:italic>\n                    ), and viscosity (\n                    <jats:italic>\u03b7<\/jats:italic>\n                    ).\n                  <\/jats:p>\n                  <jats:p>\n                    Compared with adjacent normal tissue, pathological tissue demonstrated significantly higher SWS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014), elasticity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027), viscosity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.037), and T1 relaxation time (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), along with reduced fat fraction (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Penetration rate showed a near\u2010significant increase (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.065), whereas T2 exhibited no overall difference. Subtype analysis revealed that pleomorphic adenomas had significantly higher apparent diffusion coefficient (ADC) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008), T1 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008), and T2 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008) values than Warthin tumors, with greater deviation from normal tissue. Correlation analysis showed that in normal tissue, fat fraction strongly influenced variability in SWS, T1, and ADC, with ADC demonstrating a strong negative correlation with fat fraction (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.95,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), limiting its interpretability without fat correction. In contrast, pathological tissue demonstrated a tightly coupled cluster of ADC, T1, and T2 (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.95\u20130.96, all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) reflecting water content, independent of mechanical parameters.\n                  <\/jats:p>\n                  <jats:p>These findings indicate that ex\u00a0vivo MRE combined with multiparametric MRI enables quantitative assessment of parotid tumor properties through complementary biomarkers reflecting distinct physical mechanisms. Although viscoelastic parameters alone were insufficient to differentiate all tumor subtypes, their integration with diffusion and relaxometry metrics provides a more comprehensive characterization of tumor microstructure. This multiparametric approach shows promise for translation to in\u00a0vivo applications, potentially enabling improved noninvasive tumor characterization and informing surgical planning.<\/jats:p>","DOI":"10.1002\/nbm.70361","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:00:17Z","timestamp":1784610017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiparametric Ex\u00a0Vivo Evaluation of Parotid Tumors: Feasibility and Preliminary Results"],"prefix":"10.1002","volume":"39","author":[{"given":"Wojciech","family":"Domka","sequence":"first","affiliation":[{"name":"Clinical Department of Otolaryngology University Clinical Hospital Fryderyk Chopin in Rzesz\u00f3w  Rzesz\u00f3w Poland"},{"name":"Collegium Medicum University of Rzesz\u00f3w  Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3582-4760","authenticated-orcid":false,"given":"Oliver","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Institute of Radiology Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0715-9578","authenticated-orcid":false,"given":"Vitaliy","family":"Atamaniuk","sequence":"additional","affiliation":[{"name":"Collegium Medicum University of Rzesz\u00f3w  Rzesz\u00f3w Poland"},{"name":"Department of Physics and Medical Engineering, Faculty of Mathematics and Applied Physics Rzesz\u00f3w University of Technology  Rzesz\u00f3w Poland"},{"name":"Department of Radiology Independent Public Health Care Center of the Ministry of Interior and Administration in Rzesz\u00f3w  Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Domka","sequence":"additional","affiliation":[{"name":"Clinical Department of Anesthesiology and Intensive Care University Clinical Hospital Fryderyk Chopin in Rzesz\u00f3w  Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Ha\u0144czyk","sequence":"additional","affiliation":[{"name":"Department of Radiology Independent Public Health Care Center of the Ministry of Interior and Administration in Rzesz\u00f3w  Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Kaznowska","sequence":"additional","affiliation":[{"name":"Collegium Medicum University of Rzesz\u00f3w  Rzesz\u00f3w Poland"},{"name":"Clinical Department of Pathology University Clinical Hospital Fryderyk Chopin in Rzesz\u00f3w  Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1502-4254","authenticated-orcid":false,"given":"Marzanna","family":"Obrzut","sequence":"additional","affiliation":[{"name":"Collegium Medicum University of Rzesz\u00f3w  Rzesz\u00f3w Poland"},{"name":"Department of Radiology Independent Public Health Care Center of the Ministry of Interior and Administration in Rzesz\u00f3w  Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9490-9613","authenticated-orcid":false,"given":"Weijie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Radiology Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2460-1444","authenticated-orcid":false,"given":"Ingolf","family":"Sack","sequence":"additional","affiliation":[{"name":"Institute of Radiology Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Gutkowski","sequence":"additional","affiliation":[{"name":"Collegium Medicum University of Rzesz\u00f3w  Rzesz\u00f3w Poland"},{"name":"Department of Radiology Independent Public Health Care Center of the Ministry of Interior and Administration in Rzesz\u00f3w  Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8717-0779","authenticated-orcid":false,"given":"Marian","family":"Cholewa","sequence":"additional","affiliation":[{"name":"Institute of Physical Sciences, Faculty of Exact and Technical Sciences University of Rzesz\u00f3w  Rzesz\u00f3w 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