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This study assesses the feasibility of 3D magnetic resonance fingerprinting (MRF) for simultaneous T\n                    <jats:sub>1<\/jats:sub>\n                    , T\n                    <jats:sub>2<\/jats:sub>\n                    , and proton density (M\n                    <jats:sub>0<\/jats:sub>\n                    ) mapping of the bladder wall in healthy subjects at 1.5\u2009T and 3\u2009T. A 3D MRF acquisition was combined with a deep image prior reconstruction to achieve whole\u2010bladder T\n                    <jats:sub>1<\/jats:sub>\n                    , T\n                    <jats:sub>2<\/jats:sub>\n                    , and M\n                    <jats:sub>0<\/jats:sub>\n                    mapping in 11.8\u2009min at an acquired voxel size of 1\u2009\u00d7\u20091\u2009\u00d7\u20093\u2009mm\n                    <jats:sup>3<\/jats:sup>\n                    (interpolated to 0.5\u2009\u00d7\u20090.5\u2009\u00d7\u20091.5\u2009mm\n                    <jats:sup>3<\/jats:sup>\n                    ). Twenty\u2010nine healthy subjects (14 female, 18\u201378\u2009years) were enrolled, with 16 scanned at both 1.5\u2009T and 3\u2009T. Conventional maps were acquired using MOLLI and T\n                    <jats:sub>2<\/jats:sub>\n                    \u2010prepared GRE sequences. Maps were analyzed by measuring mean global and regional T\n                    <jats:sub>1<\/jats:sub>\n                    and T\n                    <jats:sub>2<\/jats:sub>\n                    values, with spatial heterogeneity assessed using the coefficient of variation (CV). Bladder wall thickness (BWT) was measured from synthetic weighted images derived from MRF maps, compared to reference values from conventional T\n                    <jats:sub>2<\/jats:sub>\n                    \u2010weighted MRI. Mean global MRF bladder wall measurements were 984  53\u2009ms (T\n                    <jats:sub>1<\/jats:sub>\n                    ), 51.4  5.6\u2009ms (T\n                    <jats:sub>2<\/jats:sub>\n                    ), and 4.5  1.6\u2009mm (BWT) at 1.5\u2009T and 1468  118\u2009ms (T\n                    <jats:sub>1<\/jats:sub>\n                    ), 43.5  4.0\u2009ms (T\n                    <jats:sub>2<\/jats:sub>\n                    ), and 4.3  1.6\u2009mm (BWT) at 3\u2009T. MRF T\n                    <jats:sub>1<\/jats:sub>\n                    values were significantly lower than MOLLI at 1.5\u2009T (bias \u2212151\u2009ms) but not significantly different at 3\u2009T. MRF T\n                    <jats:sub>2<\/jats:sub>\n                    values were significantly lower (by 7\u20138\u2009ms) than T\n                    <jats:sub>2<\/jats:sub>\n                    \u2010prepared GRE at both field strengths. MRF exhibited lower CV than MOLLI T\n                    <jats:sub>1<\/jats:sub>\n                    mapping at 1.5\u2009T. BWT from synthetic images exhibited excellent agreement (bias .1\u2009mm) with conventional T\n                    <jats:sub>2<\/jats:sub>\n                    \u2010weighted images. Regionally, T\n                    <jats:sub>1<\/jats:sub>\n                    and T\n                    <jats:sub>2<\/jats:sub>\n                    tended to be higher in the dome and posterior wall. In an exploratory analysis, a positive association between age and T\n                    <jats:sub>2<\/jats:sub>\n                    was observed. In conclusion, 3D MRF of the bladder wall is feasible in healthy subjects, providing a baseline for translational studies to characterize pathological remodeling in LUTS.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70366","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:49:26Z","timestamp":1785239366000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["3D MR Fingerprinting for Quantitative Bladder Wall T\n                    <sub>1<\/sub>\n                    , T\n                    <sub>2<\/sub>\n                    , and M\n                    <sub>0<\/sub>\n                    Mapping in Healthy Subjects at 1.5\u2009T and 3\u2009T"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1067-6624","authenticated-orcid":false,"given":"Shane A.","family":"Wells","sequence":"first","affiliation":[{"name":"Department of Radiology University 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