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In this study, we established an interleaved multinuclear 7\u00a0T MR spectroscopy protocol to track a glucose\u2010related H signal alongside P measures of high\u2010energy phosphate metabolism during a hyperglycemic clamp. Five healthy adults completed a morning, fasted infusion experiment consisting of baseline, ramp\u2010up, and hyperglycemic stages over 120\u00a0min. Short\u2010block, short\u2010TE H single\u2010voxel spectroscopy (STEAM, TE\u00a0=\u00a011\u00a0ms; mean block duration \u00a0min) was acquired in frontal cortex and quantified using the composite glucose  taurine (Glc  Tau) measure. P was acquired with rapid 3D PETALUTE MRSI using an ultrashort echo time (UTE; TE\u00a0=\u00a065\u00a0s; 381\u00a0s per block), and high\u2010energy phosphate ratios were derived from a posterior cortical region of interest. Across participants, H Glc  Tau increased with blood glucose and showed significant elevations from baseline into hyperglycemia. In parallel, P ratios exhibited smaller but significant glycemia\u2010linked responses: both PCr\/Pi and ATP\/Pi increased with blood glucose and differed across glucose clamp stages. These findings show that H and P MRS(I) can be interleaved at 7\u00a0T to measure energy metabolism within a single session.<\/jats:p>","DOI":"10.1002\/nbm.70369","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T23:36:44Z","timestamp":1787096204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of Concurrent 1H MRS and 31P MRSI at 7\u00a0T: Brain Energy Metabolism Responses to Hyperglycemia"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3353-0305","authenticated-orcid":false,"given":"Mark","family":"Widmaier","sequence":"first","affiliation":[{"name":"Department of Radiology University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1979-1562","authenticated-orcid":false,"given":"Brooke 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