{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:48:25Z","timestamp":1792054105486,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272107"],"award-info":[{"award-number":["82272107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n The role of cerebellar glutamatergic dysfunction in cognitive impairment of Parkinson's disease (PD) remains poorly understood. Glutamate chemical exchange saturation transfer (GluCEST) imaging enables noninvasive assessment of regional glutamate levels. To investigate the associations between cerebellar GluCEST\u2013derived alterations and cognitive impairment as well as other clinical characteristics in patients with PD, 64 PD patients underwent 3\u2009T MRI including GluCEST sequence and clinical assessments. Patients were divided into PD with preserved cognition (PD\u2010CN, MoCA\u2009>\u200922,\n n<\/jats:italic>\n \u2009=\u200923) and PD with impaired cognition (PD\u2010CI, MoCA\u2009\u2264\u200922,\n n<\/jats:italic>\n \u2009=\u200941) subgroups. GluCEST\u2010derived parameters including MTR\n asym<\/jats:sub>\n , CESTR\n nr<\/jats:sup>\n , and MTR\n Rex<\/jats:sub>\n were obtained from the bilateral cerebellar cortex and white matter. Between\u2010group differences in the GluCEST\u2010derived parameters were assessed using ANOVA, adjusting for age and sex. Pearson or Spearman correlation analyses were used to examine associations between GluCEST\u2010derived parameters and cognitive performance. Benjamini\u2013Hochberg false discovery rate (FDR) correction was applied for multiple comparisons. Compared with the PD\u2010CN group, the PD\u2010CI group showed lower MTR\n asym<\/jats:sub>\n values in the bilateral cerebellar cortex (CC) and the right cerebellar white matter (CWM) (\n p<\/jats:italic>\n \u2009<\u20090.05) and a lower CESTR\n nr<\/jats:sup>\n value in the right CWM (\n p<\/jats:italic>\n \u2009=\u20090.016). Within the PD\u2010CI group, MoCA total score was negatively correlated with MTR\n Rex<\/jats:sub>\n in the left CC (\n p<\/jats:italic>\n \u2009=\u20090.013). Attention\/working memory was negatively correlated with CESTR\n nr<\/jats:sup>\n (\n p<\/jats:italic>\n \u2009=\u20090.021) and MTR\n Rex<\/jats:sub>\n (\n p<\/jats:italic>\n \u2009=\u20090.007) in the left CC. Orientation was negatively correlated with MTR\n Rex<\/jats:sub>\n in the left CWM, right CC, and right CWM (\n p<\/jats:italic>\n \u2009<\u20090.05). In addition, negative correlation between disease duration and MTR\n Rex<\/jats:sub>\n in the right CWM remained significant after FDR correction (\n p<\/jats:italic>\n \u2009=\u20090.020). Cerebellar GluCEST alterations are associated with cognitive impairment in PD. GluCEST may serve as a possible neuroimaging marker in PD.\n <\/jats:p>","DOI":"10.1002\/nbm.70393","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:07:47Z","timestamp":1789718867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebellar Glutamate Chemical Exchange Saturation Transfer Alterations Correlated With Cognitive Impairment in Parkinson's Disease"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6336-1178","authenticated-orcid":false,"given":"Xinxin","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Hospital, National Center for Gerontology Chinese Academy of Medical Sciences Beijing China"},{"name":"National Clinical Research Center for Gerontology Chinese Academy of Medical Sciences Beijing China"},{"name":"The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"},{"name":"Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0370-1517","authenticated-orcid":false,"given":"Xinyang","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Gerontology Chinese Academy of Medical Sciences Beijing China"},{"name":"The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"},{"name":"Department of Radiology, Beijing Hospital, National Center for Gerontology Chinese Academy of Medical Sciences Beijing China"},{"name":"Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"},{"name":"Peking Union Medical College Beijing 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