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Eight healthy C57BL\/6 mice, including four males and four females, underwent hepatic MRE at 7T at 300, 500 and 600\u2009Hz using RARE\u2010based sequences: classical MEG\u2010MRE and optimized OC\u2010MRE with GRAPE\u2010designed RF pulses. In both sequences, motion was encoded only along the slice direction. Each mouse was scanned on days 1, 15 and 90. Reconstruction involved phase unwrapping, directional filtering and inversion with the Algebraic Inversion of Differential Equation algorithm to estimate the shear storage modulus () on the manual liver segmentation and on an automatic circular region of interest designed for statistical analyses. Signal\u2010to\u2010noise ratio (SNR), phase\u2010to\u2010noise ratio (PNR) and intra\/interanimal reproducibility were quantified using ANOVA, intraclass correlation coefficients (ICC), Bland\u2013Altman analysis and coefficients of variation (CV). OC\u2010MRE provided a mean twofold increase in SNR compared with MEG\u2010MRE (OC\/MEG\u2009=\u20091.8\u20132.1 across frequencies) and higher PNR values.  increased with frequency for both methods, consistent with viscoelastic behavior and showed strong intermethod agreement (mean bias &lt;\u20090.05\u2009kPa;\n                    <jats:italic>r<\/jats:italic>\n                    \u2009&gt;\u20090.96,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Intra\u2010animal reproducibility was moderate at 300\u2009Hz (ICC\u2009=\u20090.31\u20130.50) and high at 500\u2013600\u2009Hz (ICC &gt;\u20090.75). No significant temporal changes in hepatic stiffness were observed across sessions. OC\u2010MRE improves signal quality while maintaining quantitative consistency with conventional MEG\u2010MRE. Its short echo time and absence of motion encoding gradients enhance robustness and make it a promising tool for longitudinal small\u2010animal studies and future clinical translation, particularly in scenarios with short transverse relaxation times (\/) such as those encountered in hepatic iron overload.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70395","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T14:47:31Z","timestamp":1789483651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimal Control\u2010Based RF Pulses Versus Classical Motion\u2010Encoding Strategies for In\u00a0Vivo Hepatic MR Elastography Across Multiple Excitation Frequencies in Mice: Reproducibility 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