{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:48:27Z","timestamp":1792054107129,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic migraine (CM) is associated with neurobiological alterations beyond episodic attacks, yet cerebral microvascular perfusion changes during the interictal phase of CM remain underexplored. Intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) provides diffusion\u2010derived pseudoperfusion parameters that reflect regional microvascular alterations in the brain parenchyma. Accordingly, this study aimed to investigate right\u2010to\u2010left hemispheric asymmetry of IVIM\u2010derived perfusion parameters in migraine\u2010implicated cortical and subcortical regions during the interictal phase of CM. Thirty patients with CM imaged during the interictal phase, along with 30 age\u2010 and sex\u2010matched healthy controls, underwent IVIM imaging. IVIM parameters, including the pseudodiffusion coefficient (\n                    <jats:italic>D*<\/jats:italic>\n                    ), perfusion fraction (\n                    <jats:italic>f<\/jats:italic>\n                    ), and their composite metric (\n                    <jats:italic>fD*<\/jats:italic>\n                    ), were estimated using a Bayesian probability\u2010based fitting algorithm. Region\u2010of\u2010interest (ROI) analysis was performed bilaterally in migraine\u2010implicated cortical and subcortical regions. Hemispheric asymmetry indices (HAIs) of IVIM parameters were calculated and compared between groups using Benjamini\u2013Hochberg (FDR) false discovery rate correction. No absolute IVIM parameter showed significant interhemispheric differences in either group after FDR correction. In addition, no significant group differences in HAI of IVIM parameters were identified across the six cortical regions or pontine tegmentum. In contrast, posterior thalamic\n                    <jats:italic>fD*<\/jats:italic>\n                    asymmetry was significantly greater in patients with CM than in controls (median HAI: 27.91 vs. 10.43;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002,\n                    <jats:italic>q<\/jats:italic>\n                    \u2009=\u20090.017). Exploratory analysis confirmed greater separation between bilateral posterior thalamic\n                    <jats:italic>fD*<\/jats:italic>\n                    measurements in CM versus control subjects (0.429 vs. 0.151\u2009\u00d7\u200910\n                    <jats:sup>\u22123<\/jats:sup>\n                    \u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    \/s;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002), whereas leave\u2010one\u2010out analysis showed that this outcome was not driven by any single participant. Interobserver agreement for HAI measurements was good for\n                    <jats:italic>D*<\/jats:italic>\n                    (ICC\u2009=\u20090.81) and moderate for\n                    <jats:italic>f<\/jats:italic>\n                    and\n                    <jats:italic>fD*<\/jats:italic>\n                    (ICC\u2009=\u20090.70 and 0.69, respectively). These findings indicate that CM is associated with increased hemispheric asymmetry of IVIM\u2010derived microvascular perfusion in the posterior thalamus during interictal phase, suggesting lateralized thalamic microvascular alterations in CM.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70403","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:50:59Z","timestamp":1789793459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Cerebral Perfusion Asymmetry in Chronic Migraine Patients Using Intravoxel Incoherent Motion (IVIM)\u2013Derived Pseudodiffusion Coefficient and Perfusion Fraction"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0661-7867","authenticated-orcid":false,"given":"Yunus Emre","family":"Senturk","sequence":"first","affiliation":[{"name":"Department of Radiology Ko\u00e7 University Hospital  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4913-6860","authenticated-orcid":false,"given":"Ahmet","family":"Peker","sequence":"additional","affiliation":[{"name":"Department of Radiology Ko\u00e7 University Hospital  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3066-1737","authenticated-orcid":false,"given":"Sabahattin","family":"Yuzkan","sequence":"additional","affiliation":[{"name":"Department of Radiology Ko\u00e7 University Hospital  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8076-9851","authenticated-orcid":false,"given":"Huseyin Ekin","family":"Ergin","sequence":"additional","affiliation":[{"name":"Department of Radiology Ko\u00e7 University Hospital  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-8800","authenticated-orcid":false,"given":"Eser","family":"Bulus","sequence":"additional","affiliation":[{"name":"Department of Neurology Ko\u00e7 University Hospital  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3175-8098","authenticated-orcid":false,"given":"Mohammed Salman","family":"Shazeeb","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00509-5"},{"key":"e_1_2_15_3_1","first-page":"1","article-title":"The International Classification of Headache Disorders","volume":"38","author":"Arnold 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