{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:48:24Z","timestamp":1792054104730,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sodium MRI can be used in musculoskeletal imaging to assess tissue composition because sodium concentration is related to glycosaminoglycan (GAG) content. In tendinopathy, the GAG content is elevated, resulting in a high signal in sodium MRI. Because biochemical changes typically precede structural alterations, sodium MRI may be a useful indicator for detecting early tendon matrix changes associated with tendinopathy. Quantitative sodium concentration determination has only been applied to Achilles tendons but not yet to smaller tendons, such as the patellar tendon. Due to its smaller diameter, the patellar tendon is more susceptible to partial volume artifacts, making accurate sodium concentration quantification more challenging. However, partial volume correction (PVC) may help overcome these difficulties. In this study, we determined the apparent tissue sodium concentration (aTSC) in seven patients with patellar tendinopathy and 20 healthy controls using clinical 3\u2009T MRI with a density\u2010adapted 3D radial MR\u2010sequence. Sodium images were corrected for partial volume effects using an in\u2010house developed PVC, called the estimated single target correction (eSTC). Additionally,\n                    <jats:sup>1<\/jats:sup>\n                    H T\n                    <jats:sub>2<\/jats:sub>\n                    * values were calculated for comparison, as they are sensitive to structural alterations. Sodium relaxation times were determined in three healthy controls, resulting in a T\n                    <jats:sub>1<\/jats:sub>\n                    of 30.2\u2009\u00b1\u20090.4\u2009ms and a biexponential T\n                    <jats:sub>2s<\/jats:sub>\n                    * of 0.7\u2009\u00b1\u20090.2\u2009ms and T\n                    <jats:sub>2l<\/jats:sub>\n                    * of 13.0\u2009\u00b1\u20090.1\u2009ms. The short component\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>s<\/jats:italic>\n                    <\/jats:sub>\n                    accounted for 35.7%\u2009\u00b1\u20092.1% of the transversal relaxation. aTSC values were 35.4\u2009\u00b1\u200910.1\u2009mM in tendinopathy patients and 21.6\u2009\u00b1\u20093.9\u2009mM in healthy controls.\n                    <jats:sup>1<\/jats:sup>\n                    H T\n                    <jats:sub>2<\/jats:sub>\n                    * values were 5.4\u2009\u00b1\u20091.9\u2009ms and 2.8\u2009\u00b1\u20090.3\u2009ms, respectively. Differences between patients and controls were significant for both parameters. These findings support the suitability of sodium MRI for quantitative assessment of the patellar tendon and demonstrate its potential for visualizing biochemical changes associated with patellar tendinopathy.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70404","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:55:53Z","timestamp":1789797353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Sodium MRI of the Human Patellar Tendon"],"prefix":"10.1002","volume":"39","author":[{"given":"Rika","family":"M\u00f6ller","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Medical Faculty University Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Jurisic","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Medical Faculty University Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas R.","family":"Drewes","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Medical Faculty University Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9748-9927","authenticated-orcid":false,"given":"Alexandra","family":"Ljimani","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Medical Faculty University Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5830-423X","authenticated-orcid":false,"given":"Hans\u2010J\u00f6rg","family":"Wittsack","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Medical Faculty University Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0948-1421","authenticated-orcid":false,"given":"Armin M.","family":"Nagel","sequence":"additional","affiliation":[{"name":"Institute of Radiology University Hospital Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen N\u00fcrnberg (FAU)  Erlangen Germany"},{"name":"Divison of Medical Physics in Radiology German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Antoch","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Medical Faculty University Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1159-863X","authenticated-orcid":false,"given":"Lena M.","family":"Wilms","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional 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