{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:48:24Z","timestamp":1792054104712,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["450799851"],"award-info":[{"award-number":["450799851"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["455422993"],"award-info":[{"award-number":["455422993"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A free\u2010breathing six\u2010echo radial stack\u2010of\u2010stars acquisition is evaluated as an alternative to Cartesian breath\u2010hold scans for pancreatic fat quantification at 3T. Pancreatic fat deposition was assessed in 18 participants with obesity enrolled in a randomized controlled lifestyle intervention study (LION) using both a Cartesian breath\u2010hold scan and a free\u2010breathing high\u2010resolution stack\u2010of\u2010stars sequence (scan times: 16\u2009s vs. 2\u2009min 55\u2009s). Pancreatic segmentations were initially generated using the VibeSegmentator and subsequently refined manually to reduce the amount of included visceral fat. The Intra\u2010observer reproducibility of the manual refinement was assessed after 3\u2009months using Dice similarity score. SNR for both scan methods was quantified using a large water phantom. Mean segmented volume and mean pancreatic proton density fat fraction (PDFF) values between radial and Cartesian scans were compared. PDFF and volume changes between baseline and post\u2010intervention were investigated for both techniques. Segmented pancreatic volumes and PDFF measurements demonstrated excellent agreement between the radial and Cartesian sequences (Volume:\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.97, ICC\u2009=\u20090.96; PDFF:\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.98, ICC\u2009=\u20090.98). Compared to the Cartesian scans, the radial scans exhibited a minor positive volume bias at higher pancreatic volumes (linear regression: 0.85\n                    <jats:italic>x<\/jats:italic>\n                    \u2009+\u20099.4\u2009cm\n                    <jats:sup>3<\/jats:sup>\n                    ; mean volume bias: 5.8\u2009cm\n                    <jats:sup>3<\/jats:sup>\n                    , 95% LoA: \u22127.1 to 18.7\u2009cm\n                    <jats:sup>3<\/jats:sup>\n                    ), alongside a proportional PDFF bias leading to slight overestimation at lower values and underestimation at higher values (linear regression: 0.88\n                    <jats:italic>x<\/jats:italic>\n                    \u2009+\u20092.1%; mean PDFF bias \u22120.2%, 95% LoA: \u22123.0 to 2.7%). Post\u2010intervention, both datasets captured significant decreases in pancreatic PDFF (mean loss 2.3%\u2009\u00b1\u20092.1%, Cartesian\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001, radial\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and volume (mean loss 8.4\u2009cm\n                    <jats:sup>3<\/jats:sup>\n                    \u2009\u00b1\u20097.7\u2009cm\n                    <jats:sup>3<\/jats:sup>\n                    ; both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The present study demonstrates the feasibility of a free\u2010breathing radial stack\u2010of\u2010stars sequence for pancreatic fat quantification at 3T and its application in adults with obesity undergoing diet\u2010induced weight loss.\n                  <\/jats:p>","DOI":"10.1002\/nbm.70407","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:51:37Z","timestamp":1790326297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantifying Pancreatic Fat Using a Free\u2010Breathing Acquisition in Adults With Obesity Undergoing Diet\u2010Induced Weight Loss\u2014Results From the LION Study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4486-7776","authenticated-orcid":false,"given":"Philipp","family":"Braun","sequence":"first","affiliation":[{"name":"Institute of Radiology, School of Medicine and Health, TUM Klinikum Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3148-010X","authenticated-orcid":false,"given":"Christoph","family":"Zoellner","sequence":"additional","affiliation":[{"name":"Institute of Radiology, School of Medicine and Health, TUM Klinikum Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8593-7091","authenticated-orcid":false,"given":"Mingming","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Radiology, School of Medicine and Health, TUM Klinikum Technical University of Munich  Munich Germany"},{"name":"Department of Radiology Ludwig Maximilian University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6656-3680","authenticated-orcid":false,"given":"Robert","family":"Graf","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, School of Medicine and Health, TUM Klinikum Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3335-3331","authenticated-orcid":false,"given":"Jonathan","family":"Stelter","sequence":"additional","affiliation":[{"name":"Institute of Radiology, School of Medicine and Health, TUM Klinikum Technical University of Munich  Munich Germany"},{"name":"Laboratory of Magnetic Resonance Imaging Systems and Methods Ecole Polytechnique Federale de Lausanne (EPFL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1752-2994","authenticated-orcid":false,"given":"Anna","family":"Reik","sequence":"additional","affiliation":[{"name":"Institute of Clinical Nutritional Medicine, School of Medicine and Health, TUM Klinikum Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hauner","sequence":"additional","affiliation":[{"name":"Institute of Clinical Nutritional Medicine, School of Medicine and Health, TUM Klinikum Technical University of Munich  Munich Germany"},{"name":"Else Kr\u00f6ner\u2010Fresenius Center for Nutritional Medicine Technical University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7557-0003","authenticated-orcid":false,"given":"Jan Stefan","family":"Kirschke","sequence":"additional","affiliation":[{"name":"Institute of 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