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While the changes of proton density fat fraction (PDFF) upon cold activation are well investigated, there is a knowledge gap regarding PDFF and  dynamics upon meal\u2010induced BAT activation. Therefore, the purpose of this study was to establish a robust pipeline to quantify PDFF and  changes in scAT in fasting control and meal intervention experiments. To that end, a motion\u2010robust radial stack\u2010of\u2010stars trajectory has been employed with a regularized iterative reconstruction algorithm, graph\u2010cut\u2010based water\u2010fat separation, affine image registration and automatic neural\u2010network\u2010based region of interest (ROI) segmentation. Next to scAT, ROIs of subcutaneous adipose tissue (SAT) and muscle have been created to compare the results to reference tissues. Multi\u2010echo gradient echo acquisitions were repeated in a total of ten volunteers before a break, in which the volunteers consumed an iso\u2010caloric meal in the meal intervention experiment. After the break, repeated multi\u2010echo gradient echo measurements were used to dynamically track the changes of both PDFF and . In the meal intervention experiment, scAT PDFF showed a stronger decrease of  compared to the fasting control experiment, in which the decrease below baseline was similar to that in SAT. Furthermore, scAT  exhibited a strong decrease to  below baseline after meal intervention, while no decrease was observed in the fasting control experiment or in SAT. Considering the observed dynamic effects and their differences to the fasting control experiment, a PDFF decrease of  and a  decrease of  could be attributed to meal\u2010induced activation of scAT.<\/jats:p>","DOI":"10.1002\/nbm.70414","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:26:53Z","timestamp":1791260813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Meal\u2010Induced Proton Density Fat Fraction and T2\u2217 Decrease in Supraclavicular Adipose Tissue"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9628-1511","authenticated-orcid":false,"given":"Johannes","family":"Raspe","sequence":"first","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology, School of Medicine and Health TUM University Hospital, Technical University of Munich (TUM)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxing","family":"Du","sequence":"additional","affiliation":[{"name":"ZIEL \u2013 Institute for Food &amp; 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