{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:40:45Z","timestamp":1792626045188,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37\u2010CA262662"],"award-info":[{"award-number":["R37\u2010CA262662"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chemical exchange saturation transfer magnetic resonance fingerprinting (CEST\u2010MRF) is a promising quantitative molecular imaging technique. To reduce scan time, current CEST\u2010MRF implementations typically use echo\u2010planar imaging (EPI) readouts, which are prone to geometric distortion and signal dropout. In this study, we developed a motion\u2010robust, geometrically accurate CEST\u2010MRF method using radial k\u2010space sampling, locally low\u2010rank reconstruction, and neural network\u2013based quantification. The acquisition schedule was optimized using deep learning, and its accuracy was validated in numerical simulations with digital phantoms. The number of spokes per measurement was determined through simulations and in\u00a0vivo ablation studies in healthy volunteers. Five healthy subjects underwent repeated scans, and regions of interest were defined for analysis. Tissue maps generated with the proposed method were compared with values obtained from nonlinear least\u2010squares (NLS) fitting of multisaturation\u2010power z\u2010spectra. Motion sensitivity and test\u2013retest reproducibility were evaluated using the coefficient of variation (CV) and intraclass correlation coefficient (ICC). Clinical feasibility was demonstrated in a subject with a history of remote middle cerebral artery infarction. The results show that 3D quantitative CEST maps can be acquired in 11\u2009min using 34 spokes per measurement. Numerical simulations yielded mean errors below 14% for all tissue parameters, while in\u00a0vivo parameter estimates agreed well with both NLS\u2010derived values and prior brain CEST\u2010MRF studies. The mean ICC across all tissue maps was 0.92 in white matter and 0.87 in gray matter, with mean intersubject CVs of 5.4% and 3.4%, respectively. The mean error between motion and no\u2010motion conditions was 8.6%. In the pathology case, changes in CEST\u2010MRF tissue parameters were consistent with clinically diagnosed cystic gliosis. This approach enables accurate and reproducible 3D quantitative CEST imaging of the brain within clinically feasible scan times.<\/jats:p>","DOI":"10.1002\/nbm.70428","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:10:53Z","timestamp":1792624253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Chemical Exchange Saturation Transfer Imaging With Golden\u2010Angle Radial k\u2010Space Sampling and Locally Low\u2010Rank Reconstruction"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3632-8094","authenticated-orcid":false,"given":"Ouri","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Medical Physics Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1407-7012","authenticated-orcid":false,"given":"Elizabeth J.","family":"Sutton","sequence":"additional","affiliation":[{"name":"Department of Radiology Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Radiology Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3782-4930","authenticated-orcid":false,"given":"Ricardo","family":"Otazo","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Department of Radiology Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/jmri.25838","article-title":"Clinical Applications of Chemical Exchange Saturation Transfer (CEST) MRI","volume":"47","author":"Jones K. M.","year":"2018","journal-title":"Journal of Magnetic Resonance Imaging"},{"issue":"22","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"6463","DOI":"10.1158\/0008-5472.CAN-16-0825","article-title":"In Vivo Imaging of Tumor Metabolism and Acidosis by Combining PET and MRI\u2010CEST pH Imaging","volume":"76","author":"Longo D. L.","year":"2016","journal-title":"Cancer Research"},{"issue":"1","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10555-019-09782-9","article-title":"Imaging Tumor Acidosis: A Survey of the Available Techniques for Mapping In\u00a0Vivo Tumor pH","volume":"38","author":"Anemone A.","year":"2019","journal-title":"Cancer and Metastasis Reviews"},{"issue":"1","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40658-016-0155-2","article-title":"An Overview of CEST MRI for Non\u2010MR Physicists","volume":"3","author":"Wu B.","year":"2016","journal-title":"EJNMMI Physics"},{"issue":"7440","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature11971","article-title":"Magnetic Resonance Fingerprinting","volume":"495","author":"Ma 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