{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:48:41Z","timestamp":1791514121813,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,7,23]],"date-time":"2001-07-23T00:00:00Z","timestamp":995846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010752","name":"Ludwig Boltzmann Institute for Clinical and Experimental Radiology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010752","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2001,8]]},"abstract":"Abstract<\/jats:title>Longitudinal and transverse relaxation times were measured for proton MRS signals from human brain metabolites at 3\u2005T using a short\u2010echo STEAM protocol and a surface coil as a transmitter\/receiver. Volumes of interest containing mostly grey or mostly white matter were selected in occipital lobes of healthy subjects and relaxation times for the following resonances were obtained: N<\/jats:italic>\u2010acetylaspartate at 2.01\u2005ppm (T<\/jats:italic>1<\/jats:sub> and T<\/jats:italic>2<\/jats:sub>), glutamate at 2.35\u2005ppm (T<\/jats:italic>1<\/jats:sub>), creatine at 3.03 and 3.92\u2005ppm (T<\/jats:italic>1<\/jats:sub> and T<\/jats:italic>2<\/jats:sub>), choline\u2010containing substances at 3.22\u2005ppm (T<\/jats:italic>1<\/jats:sub> and T<\/jats:italic>2<\/jats:sub>), myo<\/jats:italic>\u2010inositol at 3.57 and 3.65\u2005ppm (T<\/jats:italic>1<\/jats:sub>) and the overlapping signals of glutamate and glutamine at 3.75\u2005ppm (T<\/jats:italic>1<\/jats:sub>). The T<\/jats:italic>1<\/jats:sub> relaxation times obtained range from 0.97 to 1.47 s for grey matter and from 0.87 to 1.35 s for white matter. On the other hand, T<\/jats:italic>2<\/jats:sub> relaxation times range from 116 to 247\u2005ms and from 141 to 295\u2005ms in grey and white matter, respectively. Generally, the T<\/jats:italic>1<\/jats:sub> values measured at 3\u2005T are close to the previously published data found at 1.5, 2 and 4.1 T. Also, the T<\/jats:italic>2<\/jats:sub> values confirm the previously observed decrease in transverse relaxation times with increasing static magnetic field. The proton relaxation times obtained will allow improved sequence design and spectra quantitation at 3 T, currently tested for enhanced clinical applications. Copyright \u00a9 2001 John Wiley & Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.713","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T17:50:36Z","timestamp":1030297836000},"page":"325-331","source":"Crossref","is-referenced-by-count":288,"title":["Proton T<\/i>1<\/sub> and T<\/i>2<\/sub> relaxation times of human brain metabolites at 3 Tesla"],"prefix":"10.1002","volume":"14","author":[{"given":"Vladim\u00edr","family":"Mlyn\u00e1rik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewald","family":"Moser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,7,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910110105"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1940080305"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910300405"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1940080402"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910320504"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330215"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199901)41:1<204::AID-MRM29>3.0.CO;2-7"},{"key":"e_1_2_1_9_2","unstructured":"BriefEE WhittallKP LiDKB MacKayAL. 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