{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:20:01Z","timestamp":1770906001256,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T00:00:00Z","timestamp":1072051200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Saturation recovery spectra (STEAM) were acquired at 1.5\u2009T with 7 <jats:italic>TR<\/jats:italic>s ranging from 530 to 5000\u2009ms and a constant <jats:italic>TE<\/jats:italic> of 30\u2009ms in voxels (7.2\u2009ml) located in occipital grey, parietal white and frontal white matter (10 subjects each location). Spectra were also acquired at 7, 21 and 37\u00b0C from separate 100\u2009m<jats:sc>m<\/jats:sc> solutions of inositol (Ins), choline\u2010containing compounds (Cho), <jats:italic>N<\/jats:italic>\u2010acetyl\u2010aspartate (NAA) and creatine. Simulations of <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> fits with 2, 3 and 7 <jats:italic>TR<\/jats:italic>s demonstrated that at typical SNR there is potential for both inaccurate and biased results. <jats:italic>In vivo<\/jats:italic>, different metabolites had significantly different <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>s within the same brain volume. The same order from shortest to longest <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> (Ins, Cho, NAA, creatine) was found for all three brain regions. The order (Ins, NAA, creatine, Cho) was found in the metabolite solutions and was consistent with a simple model in which <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> is inversely proportional to molecular weight. For all individual metabolites, <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> increased from occipital grey to parietal white to frontal white matter. This study demonstrates that, in spectra acquired with <jats:italic>TR<\/jats:italic> near 1\u2009s, <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> weightings are substantially different for metabolites within a single tissue and also for the same metabolites in different tissues. 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